Neuropsychological sequelae of non-central nervous system cancer and cancer therapy.

Full Abstract

Cancer patients report numerous adverse symptoms associated with their disease and treatment including cognitive dysfunction, fatigue, and affective distress. Cognitive dysfunction is ubiquitous in patients with primary central nervous system (CNS) cancer and recent evidence has documented similar deficits in patients with non-CNS cancer as well. Both the cancer itself and treatments including chemotherapy, biological response modifiers, and hormonal therapies have been demonstrated to adversely impact cognitive and neurobehavioral function. Neuroimaging and neurophysiological investigations have likewise revealed alterations in brain function that are helping to account for the nature of these cognitive disorders. Similarly, preclinical animal research is assisting to identify the pathophysiological mechanisms that underlie treatment-related neurotoxicities. The coalescence of multidisciplinary clinical and research efforts hold promise for the development of interventions that may offer neuroprotection in addition to currently available symptomatic therapies and cognitive rehabilitation techniques.

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Author information

Author/s: Wefel, Jeffrey S (JS); Witgert, Mariana E (ME); Meyers, Christina A (CA);

Affiliation: Department of Neuro-Oncology, Section of Neuropsychology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 431, Houston, TX 77030-4009, USA. JWEFEL@MDANDERSON.ORG

Journal and publication information

Publication Type: Journal Article; Review

Journal: Neuropsychology review (Neuropsychol Rev), published in United States. (Language: eng)

Reference: 2008-Jun; vol 18 (issue 2) : pp 121-31

Dates: Created 2008/06/09; Completed 2008/08/26;

PMID: 18415683, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Cognition Disorders - etiology; genetics
Drug Therapy - methods
Hormones - therapeutic use
Humans

Immunologic Factors - therapeutic use
Neoplasms - classification; complications; therapy
Neuropsychological Tests
Neuropsychology
Quality of Life

Associated Chemicals: Hormones (0) ; Immunologic Factors (0)

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