Cardiac troponin T release after prolonged strenuous exercise.

Full Abstract

Over the past 2 decades, there has been a large interest in cardiac troponin T (cTnT) elevations, which are often seen following endurance sport events. There have been many reports on this topic, although sometimes with different approaches. We reviewed the available literature on cTnT elevations after prolonged strenuous exercise and discovered profound differences in the percentage of subjects reported to have elevated cTnT concentrations. This could partly be attributed to differences in immunoassay characteristics, such as cross-reactivity with skeletal troponin T, and the use of different cut-off values used in the different studies. The elevations were transient, with levels decreasing to pre-event concentrations within 24-48 hours. This might be explained by the relatively short half-life of cTnT, or water imbalance during and after the event. The release mechanism of cTnT, as well as the long-term positive or negative effects, remains unclear. Future research should therefore be aimed at clarifying the release mechanism of cTnT. Furthermore, the benefits and the possible long-term negative aspects of prolonged exercise should be evaluated.

Author information

Author/s: Michielsen, Etienne C H J (EC); Wodzig, Will K W H (WK); Van Dieijen-Visser, Marja P (MP);

Affiliation: Department of Clinical Chemistry, University Hospital Maastricht, Maastricht, the Netherlands. etiennemichielsen(-atsign-)gmail.com

Journal and publication information

Publication Type: Journal Article; Review

Journal: Sports medicine (Auckland, N.Z.) (Sports Med), published in New Zealand. (Language: eng)

Reference: 2008-; vol 38 (issue 5) : pp 425-35

Dates: Created 2008/04/17; Completed 2008/08/28;

PMID: 18416595, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.