Research article summary (published 29 Jun 2008):

Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules.

Full Abstract

Some immune system proteins have recently been implicated in the development and plasticity of neuronal connections. Notably, proteins of the major histocompatibility complex 1 (MHC class 1) have been shown to be involved in synaptic plasticity in the hippocampus and the development of projection patterns in the visual system. We examined the possible role for the MHC class 1 proteins in one well-characterized example of synaptic exuberance and subsequent refinement, the climbing fiber (CF) to Purkinje cell (PC) synapse. Cerebella from adult mice deficient for two MHC genes, H2-D1 and H2-K1, and for beta2-microglobulin gene were examined for evidence of deficient elimination of supernumerary CF synapses on their PCs. Electrophysiological and morphological evidence showed that, despite the absence of these MHC class 1 molecules, adult PCs in these transgenic mice are monoinnervated as in wild-type animals. These findings indicate that, at the level of restriction of afferent number at this synapse, functional MHC class 1 proteins are not required. (Copyright) 2008 Wiley Periodicals, Inc.

Author information

Author/s: Letellier, Mathieu (M); Willson, Melina L (ML); Gautheron, Vanessa (V); Mariani, Jean (J); Lohof, Ann M (AM);

Affiliation: Centre National de la Recherche Scientifique, Université Pierre et Marie Curie-Paris, Unité Mixte de Recherche 7102-Neurobiologie des Processus Adaptatifs, F-75005 Paris, France.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Developmental neurobiology (Dev Neurobiol), published in United States. (Language: eng)

Reference: 2008-Jul; vol 68 (issue 8) : pp 997-1006

Dates: Created 2008/06/18; Completed 2008/08/22;

PMID: 18418877, status: MEDLINE (last retrieved date: 2/18/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals Ataxia - genetics; metabolism; physiopathology Cerebellum - cytology; metabolism Electrophysiology Excitatory Postsynaptic Potentials - physiology Gait - physiology Histocompatibility Antigens Class I - genetics; metabolism Immunohistochemistry Mice Mice, Inbred C57BL Mice, Knockout Mice, Neurologic Mutants

Mice, Neurologic Mutants Mice, Transgenic Microscopy, Confocal Microscopy, Fluorescence Nerve Fibers - metabolism; physiology Neuronal Plasticity - physiology Olivary Nucleus - anatomy & histology; ultrastructure Patch-Clamp Techniques Purkinje Cells - cytology; metabolism; physiology Receptors, Metabotropic Glutamate - genetics; metabolism Synapses - physiology beta 2-Microglobulin - genetics; metabolism

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Histocompatibility Antigens Class I (0) ; Receptors, Metabotropic Glutamate (0) ; beta 2-Microglobulin (0)

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