Both the hippocampus and striatum are involved in consolidation of motor sequence memory.

Full Abstract

Functional magnetic resonance imaging (fMRI) was used to investigate the cerebral correlates of motor sequence memory consolidation. Participants were scanned while training on an implicit oculomotor sequence learning task and during a single testing session taking place 30 min, 5 hr, or 24 hr later. During training, responses observed in hippocampus and striatum were linearly related to the gain in performance observed overnight, but not over the day. Responses in both structures were significantly larger at 24 hr than at 30 min or 5 hr. Additionally, the competitive interaction observed between these structures during training became cooperative overnight. These results stress the importance of both hippocampus and striatum in procedural memory consolidation. Responses in these areas during training seem to condition the overnight memory processing that is associated with a change in their functional interactions. These results show that both structures interact during motor sequence consolidation to optimize subsequent behavior.

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Author information

Author/s: Albouy, Geneviève (G); Sterpenich, Virginie (V); Balteau, Evelyne (E); Vandewalle, Gilles (G); Desseilles, Martin (M); Dang-Vu, Thanh (T); Darsaud, Annabelle (A); Ruby, Perrine (P); Luppi, Pierre-Hervé (PH); Degueldre, Christian (C); Peigneux, Philippe (P); Luxen, André (A); Maquet, Pierre (P);

Affiliation: Cyclotron Research Centre, University of Liège, B-4000 Liège, Belgium.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuron (Neuron), published in United States. (Language: eng)

Reference: 2008-Apr; vol 58 (issue 2) : pp 261-72

Dates: Created 2008/04/28; Completed 2008/05/28;

PMID: 18439410, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Analysis of Variance
Brain Mapping
Corpus Striatum - blood supply; physiology
Eye Movements - physiology; radiation effects
Female
Hippocampus - blood supply; physiology
Humans

Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging
Male
Memory - physiology
Oxygen - blood
Reaction Time - physiology
Serial Learning - physiology
Task Performance and Analysis

Associated Chemicals: Oxygen (7782-44-7)

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