Research article summary (published 23 Apr 2008):

Beta-adrenergic receptor activation during distinct patterns of stimulation critically modulates the PKA-dependence of LTP in the mouse hippocampus.

Full Abstract

Activation of beta-adrenergic receptors (beta-ARs) enhances hippocampal memory consolidation and long-term potentiation (LTP), a likely mechanism for memory storage. One signaling pathway linked to beta-AR activation is the cAMP-PKA pathway. PKA is critical for the consolidation of hippocampal long-term memory and for the expression of some forms of long-lasting hippocampal LTP. How does beta-AR activation affect the PKA-dependence, and persistence, of LTP elicited by distinct stimulation frequencies? Here, we use in vitro electrophysiology to show that patterns of stimulation determine the temporal phase of LTP affected by beta-AR activation. In addition, only specific patterns of stimulation recruit PKA-dependent LTP following beta-AR activation. Impairments of PKA-dependent LTP maintenance generated by pharmacologic or genetic deficiency of PKA activity are also abolished by concurrent activation of beta-ARs. Taken together, our data show that, depending on patterns of synaptic stimulation, activation of beta-ARs can gate the PKA-dependence and persistence of synaptic plasticity. We suggest that this may allow neuromodulatory receptors to fine-tune neural information processing to meet the demands imposed by numerous synaptic activity profiles. This is a form of "metaplasticity" that could control the efficacy of consolidation of hippocampal long-term memories.

Author information

Author/s: Gelinas, Jennifer N (JN); Tenorio, Gustavo (G); Lemon, Neal (N); Abel, Ted (T); Nguyen, Peter V (PV);

Affiliation: Department of Physiology, University of Alberta School of Medicine, Edmonton, Alberta T6G 2H7, Canada.

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Learning & memory (Cold Spring Harbor, N.Y.) (Learn Mem), published in United States. (Language: eng)

Reference: 2008-; vol 15 (issue 5) : pp 281-9

Dates: Created 2008/04/28; Completed 2008/07/21; Revised 2009/05/04;

PMID: 18441285, status: MEDLINE (last retrieval date: 5/5/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adrenergic beta-Agonists - administration & dosage; pharmacology Animals Carbazoles - administration & dosage; pharmacology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Electric Stimulation Enzyme Inhibitors - administration & dosage; pharmacology Female Hippocampus - drug effects; metabolism Intracellular Signaling Peptides and Proteins - administration & dosage; pharmacology Isoproterenol - administration & dosage; pharmacology Locus Coeruleus - drug effects Long-Term Potentiation - drug effects

Long-Term Potentiation - drug effects Memory - drug effects Mice Mice, Inbred C57BL Mice, Mutant Strains Mice, Transgenic Nerve Net - drug effects Neuronal Plasticity - drug effects Pyrroles - administration & dosage; pharmacology RGS Proteins - drug effects Receptors, Adrenergic, beta - drug effects; metabolism Synaptic Transmission - drug effects

Associated Chemicals: Adrenergic beta-Agonists (0) ; Carbazoles (0) ; Enzyme Inhibitors (0) ; Intracellular Signaling Peptides and Proteins (0) ; Pyrroles (0) ; RGS Proteins (0) ; Receptors, Adrenergic, beta (0) ; protein kinase modulator (0) ; KT 5720 (108068-98-0) ; Isoproterenol (7683-59-2) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)

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