A specialized forebrain circuit for vocal babbling in the juvenile songbird.

Full Abstract

Young animals engage in variable exploratory behaviors essential for the development of neural circuitry and adult motor control, yet the neural basis of these behaviors is largely unknown. Juvenile songbirds produce subsong-a succession of primitive vocalizations akin to human babbling. We found that subsong production in zebra finches does not require HVC (high vocal center), a key premotor area for singing in adult birds, but does require LMAN (lateral magnocellular nucleus of the nidopallium), a forebrain nucleus involved in learning but not in adult singing. During babbling, neurons in LMAN exhibited premotor correlations to vocal output on a fast time scale. Thus, juvenile singing is driven by a circuit distinct from that which produces the adult behavior-a separation possibly general to other developing motor systems.

Author information

Author/s: Aronov, Dmitriy (D); Andalman, Aaron S (AS); Fee, Michale S (MS);

Affiliation: McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Grants: MH067105 (Agency:NIMH NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Science (New York, N.Y.) (Science), published in United States. (Language: eng)

Reference: 2008-May; vol 320 (issue 5876) : pp 630-4

Dates: Created 2008/05/02; Completed 2008/05/13;

PMID: 18451295, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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