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| Research article summary (published 30 Jul 2008): |
Comparable morphometric data of pathological nerve obtained using the three-window sampling method and total fiber quantification.
Full Abstract
Morphometric analysis of nerve biopsy provides data of structural changes that are essential for early detection of peripheral neuropathy. Because of the laborious work associated with the total fiber quantification, various sampling methods have been introduced with controversial accuracy. Three-window sampling technique has been recently proposed to provide the accurate morphometric data of normal human sural nerve. However, its application in the diseased nerve has not been validated. This study, therefore, compared the morphometric data of nerve biopsies from 12 patients with various neuropathies obtained using this sampling method and those obtained by total fiber analysis. Total number, density, and diameter of myelinated fibers including myelin thickness and g ratio were analyzed. Intraclass correlation coefficients ranging from 0.95 to 0.99 indicate the high agreement between the data derived from the two methods in these parameters. This finding suggests the accuracy of the three-window sampling technique in the morphometric study of nerve with pathological alterations.(c) 2008 Wiley-Liss, Inc.
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Author information
Author/s: Agthong, Sithiporn (S); Chentanez, Vilai (V); Koonam, Junjira (J); Kaewsema, Atitaya (A);
Affiliation: Peripheral Nerve Research Unit, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand. fmedsat@md.chula.ac.th
Journal and publication information
Publication Type: Comparative Study; Journal Article
Journal: Microscopy research and technique (Microsc Res Tech), published in United States. (Language: eng)
Reference: 2008-Aug; vol 71 (issue 8) : pp 585-7
Dates: Created 2008/07/30; Completed 2008/09/30;
PMID: 18452189, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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