Suppression of the P(b) (P(1)) component of the auditory middle latency response with contralateral masking.

Full Abstract

OBJECTIVE:
In this study, the effects of contralateral noise or speech on middle latency response (MLR) components P(a) and P(b) (P(1) or P50) were studied using high rates clicks in normal hearing awake adult subjects.

METHODS:
One standard (4.88 Hz) and four jittered click sequences (24.4, 39.1, 58.6, 78.1 Hz) at different mean rates were monaurally presented to ten subjects. The contralateral ears were stimulated with continuous pink noise, recorded speech or no stimulus for control. Overlapping MLR responses to jittered click stimuli were deconvolved using the frequency domain continuous loop averaging deconvolution (CLAD).

RESULTS:
The recordings show that contralateral noise or speech stimulation suppresses P(b) component greatly at rates around 40 Hz while earlier components (ABR and P(a)) are not significantly affected. The suppression of the P(b) component is about 50% with some latency reduction.

CONCLUSIONS:
The results show that the P(b) component of the MLR is significantly affected by contralateral stimulus at resonance rates at around 40 Hz. It appears that the contralateral noise obliterates the amplitude enlargement due to resonance effect.

SIGNIFICANCE:
These findings show that the P(b) is generated very differently from the P(a) component and strongly inhibited by the contralateral ear. These results also explain the previously observed masking of the 40 Hz auditory steady-state responses (ASSR) with contralateral noise.

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Author information

Author/s: Ozdamar, Ozcan (O); Bohórquez, Jorge (J);

Affiliation: Department of Biomedical Engineering, University of Miami, P.O. Box 248294, Coral Gables, FL 33124, USA. oozdamar@miami.edu

Journal and publication information

Publication Type: Journal Article

Journal: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (Clin Neurophysiol), published in Netherlands. (Language: eng)

Reference: 2008-Aug; vol 119 (issue 8) : pp 1870-80

Dates: Created 2008/07/08; Completed 2008/09/24;

PMID: 18467167, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acoustic Stimulation
Adult
Analysis of Variance
Dose-Response Relationship, Radiation
Electroencephalography - methods
Evoked Potentials, Auditory - physiology
Female
Functional Laterality - physiology

Functional Laterality - physiology
Humans
Male
Middle Aged
Noise
Perceptual Masking - physiology
Reaction Time - physiology
Time Factors

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