Research article summary (published 10 May 2008):

Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib.

Full Abstract

BACKGROUND: Observational studies have shown reduced risk of Alzheimer dementia in users of nonsteroidal anti-inflammatory drugs. OBJECTIVE: To evaluate the effects of naproxen sodium and celecoxib on cognitive function in older adults. DESIGN: Randomized, double-masked chemoprevention trial. SETTING: Six US memory clinics. PARTICIPANTS: Men and women aged 70 years and older with a family history of Alzheimer disease; 2117 of 2528 enrolled had follow-up cognitive assessment. INTERVENTIONS: Celecoxib (200 mg twice daily), naproxen sodium (220 mg twice daily), or placebo, randomly allocated in a ratio of 1:1:1.5, respectively. MAIN OUTCOME MEASURES: Seven tests of cognitive function and a global summary score measured annually. RESULTS: Longitudinal analyses showed lower global summary scores over time for naproxen compared with placebo (- 0.05 SDs; P = .02) and lower scores on the Modified Mini-Mental State Examination over time for both treatment groups compared with placebo (- 0.33 points for celecoxib [P = .04] and - 0.36 points for naproxen [P = .02]). Restriction of analyses to measures collected from persons without dementia attenuated the treatment group differences. Analyses limited to measures obtained while participants were being issued study drugs produced results similar to the intention-to-treat analyses. CONCLUSIONS: Use of naproxen or celecoxib did not improve cognitive function. There was weak evidence for a detrimental effect of naproxen.

Author information

Author/s: ADAPT Research Group; Martin, Barbara K (BK); Szekely, Christine (C); Brandt, Jason (J); Piantadosi, Steven (S); Breitner, John C S (JC); Craft, Suzanne (S); Evans, Denis (D); Green, Robert (R); Mullan, Michael (M);

Grants: U01 AG15477 (Agency:NIA NIH HHS)

Journal and publication information

Publication Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural

Journal: Archives of neurology (Arch Neurol), published in United States. (Language: eng)

Reference: 2008-Jul; vol 65 (issue 7) : pp 896-905

Dates: Created 2008/07/15; Completed 2008/08/04; Revised 2009/04/16;

PMID: 18474729, status: MEDLINE (last retrieval date: 4/16/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Arch Neurol. 2009 Apr;66(4):539-40; author reply 540. (PMID: 19364945)

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Aged, 80 and over Alzheimer Disease - drug therapy; pathology; psychology Anti-Inflammatory Agents, Non-Steroidal - adverse effects; therapeutic use Cognition - drug effects; physiology Cognition Disorders - drug therapy; pathology; psychology Double-Blind Method Female Follow-Up Studies

Follow-Up Studies Humans Longitudinal Studies Male Naproxen - adverse effects; therapeutic use Pyrazoles - therapeutic use Sulfonamides - therapeutic use Time Factors Treatment Outcome

Associated Chemicals: Anti-Inflammatory Agents, Non-Steroidal (0) ; Pyrazoles (0) ; Sulfonamides (0) ; celecoxib (169590-42-5) ; Naproxen (22204-53-1)

Related articles

These are the highest related articles currently in the database:

• Anti-inflammatory drugs fall short in Alzheimer's disease. 30 Aug 2008
• NSAIDs and Alzheimer's disease: how far to generalise from trials? 30 Aug 2003
• Nimesulide in the treatment of advanced cancer pain. Double-blind comparison with naproxen. 30 Jul 1992
• Comparative efficacy and safety of celecoxib and naproxen in the treatment of osteoarthritis of the hip. 30 Oct 2001
• Long-term efficacy and safety of celecoxib in Alzheimer's disease. 24 Oct 2006
• A randomized, double-blind, multicenter trial of nimesulide-beta-cyclodextrin versus naproxen in patients with osteoarthritis. 30 Mar 2002
• Safety of short-term administration of celecoxib in decompensated cirrhosis. 29 Jun 2005
• Functional status and health-related quality of life of elderly osteoarthritic patients treated with celecoxib. 27 Feb 2001
• The postoperative analgesic efficacy and safety of piroxicam (FDDF) and naproxen sodium. 30 Dec 1997
• Nimesulide in the treatment of advanced cancer pain. Double-blind comparison with naproxen. 30 Dec 1992

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.