Mass screening-based case-control study of diet and prostate cancer in Changchun, China.

Full Abstract

AIM:
To investigate possible correlation factors for prostate cancer by a population-based case-control study in China.

METHODS:
We carried out a mass screening of prostate cancer in Changchun, China, using a prostate-specific antigen assisted by Japan International Cooperation Agency. From June 1998 to December 2000, 3 940 men over 50 years old were screened. Of these, 29 men were diagnosed with prostate cancer. We selected 28 cases and matched them with controls of low prostate-specific antigen value (< 4.1 ng/mL) by 1:10 according to age and place of employment. A case-control study of diet and prostate cancer was then carried out.

RESULTS:
After adjustment for education, body mass index (BMI), smoking, alcohol consumption, marriage and diet, intake of soybean product was discovered to be inversely related to prostate cancer. Men who consumed soybean product more than twice per week on different days had a multivariate odds ratio (OR) of 0.38 (95% confidence interval [CI], 0.13-1.12). In addition, men who consumed soybean products more than once per day had a multivariate OR of 0.29 (95% CI, 0.11-0.79) compared with men who consumed soybean products less than once per week. The P for trend was 0.02, which showed significant difference. There was no significant difference in P trend for any dairy food. Even when we matched the cases and controls by other criteria, we found that soybean food was the only preventive factor associated with prostate cancer.

CONCLUSION:
Our study suggests that consumption of soybeans, one of the most popular foods in Asia, would decrease the risk of prostate cancer.

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Author information

Author/s: Li, Xiao-Meng (XM); Li, Jiang (J); Tsuji, Ichiro (I); Nakaya, Naoki (N); Nishino, Yoshikazu (Y); Zhao, Xue-Jian (XJ);

Affiliation: School of Life Sciences, Northeast Normal University, Changchun, China. lixm441(-atsign-)nenu.edu.cn

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Asian journal of andrology (Asian J Androl), published in China. (Language: eng)

Reference: 2008-Jul; vol 10 (issue 4) : pp 551-60

Dates: Created 2008/05/14; Completed 2008/07/29;

PMID: 18478158, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Aged, 80 and over
Case-Control Studies
China - epidemiology
Diet
Humans
Incidence

Male
Mass Screening - methods
Middle Aged
Multivariate Analysis
Prostate-Specific Antigen - blood
Prostatic Neoplasms - diagnosis; epidemiology; prevention & control
Soybeans

Associated Chemicals: Prostate-Specific Antigen (EC 3.4.21.77)

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