Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine.

Full Abstract

Aged dogs demonstrate cognitive decline that is linked to brain aging. The purpose of the present study was to examine if a commercially available nutraceutical supplement that may be neuroprotective and contains phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine could improve cognitive function in aged beagles. Nine aged beagles were tested on performance on a delayed-non-matching-to-position task, which is a neuropsychological test of short-term visuospatial memory. All subjects were tested on 5 baseline sessions; then, to assess the supplement, a crossover design was used in which 1 group received the supplement and the other a control substance in the 1st phase, with treatment conditions being reversed in the 2nd phase. Performance accuracy was significantly improved in supplemented dogs compared with control dogs and the effect was long lasting. These findings suggest that the nutraceutical supplement can improve memory in aged dogs.

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Author information

Author/s: Araujo, Joseph A (JA); Landsberg, Gary M (GM); Milgram, Norton W (NW); Miolo, Alda (A);

Affiliation: Department of Pharmacology, University of Toronto, 1 King's College Circle, Toronto, Ontario. josepha(-atsign-)cancog.com

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Canadian veterinary journal. La revue vétérinaire canadienne (Can Vet J), published in Canada. (Language: eng)

Reference: 2008-Apr; vol 49 (issue 4) : pp 379-85

Dates: Created 2008/05/16; Completed 2008/06/17;

PMID: 18481547, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aging - psychology
Animals
Cross-Over Studies
Dietary Supplements
Dogs - psychology
Female
Ginkgo biloba - chemistry
Male
Memory, Short-Term - drug effects

Neuropsychological Tests
Phosphatidylserines - pharmacology
Plant Extracts - pharmacology
Pyridoxine - pharmacology
Random Allocation
Safety
Treatment Outcome
Vitamin B Complex - pharmacology
Vitamin E - pharmacology

Associated Chemicals: Phosphatidylserines (0) ; Plant Extracts (0) ; Vitamin B Complex (12001-76-2) ; Vitamin E (1406-18-4) ; Pyridoxine (65-23-6)

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