Advances in the field of cannabinoid--opioid cross-talk.

Full Abstract

A remarkable amount of literature has been generated demonstrating the functional similarities between the endogenous opioid and cannabinoid systems. Anatomical, biochemical and molecular data support the existence of reciprocal interactions between these two systems related to several pharmacological responses including reward, cognitive effects, and the development of tolerance and dependence. However, the assessment of the bidirectionality of these effects has been difficult due to their variety and complexity. Reciprocal interactions have been well established for the development of physical dependence. Cross-tolerance and cross-sensitization, although not always bidirectional, are also supported by a number of evidence, while less data have been gathered regarding the relationship of these systems in cognition and emotion. Nevertheless, the most recent advances in cannabinoid-opioid cross-modulation have been made in the area of drug craving and relapse processes. The present review is focused on the latest developments in the cannabinoid-opioid cross-modulation of their behavioural effects and the possible neurobiological substrates involved.

Author information

Author/s: Robledo, Patricia (P); Berrendero, Fernando (F); Ozaita, Andrés (A); Maldonado, Rafael (R);

Affiliation: Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Spain.

Grants: 1R01DA016768 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Addiction biology (Addict Biol), published in England. (Language: eng)

Reference: 2008-Jun; vol 13 (issue 2) : pp 213-24

Dates: Created 2008/05/16; Completed 2008/07/08;

PMID: 18482431, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Brain - drug effects; physiopathology
Cannabinoids - pharmacology
Cognition - drug effects; physiology
Drug Tolerance
Emotions - drug effects; physiology
Endocannabinoids - physiology
Endorphins - physiology
Humans
Marijuana Abuse - physiopathology

Marijuana Abuse - physiopathology
Motivation
Narcotics - pharmacology
Neurotransmitter Agents - metabolism
Opioid-Related Disorders - physiopathology
Receptor Cross-Talk - drug effects; physiology
Receptor, Cannabinoid, CB1 - drug effects; physiology
Receptor, Cannabinoid, CB2 - drug effects; physiology
Receptors, Opioid - drug effects; physiology
Substance Withdrawal Syndrome - physiopathology

Associated Chemicals: Cannabinoids (0) ; Endocannabinoids (0) ; Endorphins (0) ; Narcotics (0) ; Neurotransmitter Agents (0) ; Receptor, Cannabinoid, CB1 (0) ; Receptor, Cannabinoid, CB2 (0) ; Receptors, Opioid (0)

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