Reference values for clinical chemistry tests during normal pregnancy.

Full Abstract

OBJECTIVE:
Reference values are usually defined based on blood samples from healthy men or nonpregnant women. This is not optimal as many biological markers changes during pregnancy and adequate reference values are of importance for correct clinical decisions. There are only few studies on the variations of laboratory tests during normal pregnancies, especially during the first two trimesters. It is thus a need to establish such reference values.

DESIGN:
Longitudinal study of laboratory markers in normal pregnancies.

SETTING:
Uppsala University Hospital, Sweden.

POPULATION:
Healthy pregnant females.

METHODS:
We have studied 25 frequently used laboratory tests during 52 normal pregnancies. Each woman was sampled up to nine times and the samples were divided according to collection time into the following groups:
gestational week 7-17; week 17-24; week 24- 28; week 28-31; week 31-34; week 34-38; predelivery (0-2 weeks before delivery) and postpartum (> 6 weeks after delivery). The 2.5 and 97.5 percentiles for these markers were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values.

RESULTS:
Reference intervals are reported for plasma alanine aminotransferase, albumin, alkaline phosphatase, pancreas amylase, apolipoprotein A1, apolipoprotein B, aspartate aminotransferase, bilirubin, calcium, chloride, creatinine, cystatin C, ferritin, gamma-glutamyltransferase, iron, lactate dehydrogenase, magnesium, phosphate, potassium, sodium, transferrin, triglycerides, thyroid-stimulating hormone, urate and urea during these pregnancy periods.

CONCLUSIONS:
Most of the analytes change during normal pregnancy. It is thus of importance to use special reference values during pregnancy.

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Author information

Author/s: Larsson, A (A); Palm, M (M); Hansson, L-O (LO); Axelsson, O (O);

Affiliation: Department of Medical Sciences, Clinical Chemistry, University Hospital, Uppsala, Sweden. anders.larsson(-atsign-)akademiska.se

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: BJOG : an international journal of obstetrics and gynaecology (BJOG), published in England. (Language: eng)

Reference: 2008-Jun; vol 115 (issue 7) : pp 874-81

Dates: Created 2008/05/19; Completed 2008/07/21;

PMID: 18485166, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Biological Markers - analysis
Clinical Chemistry Tests - standards
Female
Humans
Infant

Infant
Infant, Newborn
Pregnancy - physiology
Pregnancy Trimesters
Prenatal Diagnosis - standards
Reference Values

Associated Chemicals: Biological Markers (0)

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