Inhibition of mGluR1 and IP3Rs impairs long-term memory formation in young chicks.

Full Abstract

Calcium (Ca(2+)) is involved in a myriad of cellular functions in the brain including synaptic plasticity. However, the role of intracellular Ca(2+) stores in memory processing remains poorly defined. The current study explored a role for glutamate-dependent intracellular Ca(2+) release in memory processing via blockade of metabotropic glutamate receptor subtype 1 (mGluR1) and inositol (1,4,5)-trisphosphate receptors (IP(3)Rs). Using a single-trial discrimination avoidance task developed for the young chick, administration of the specific and potent mGluR1 antagonist JNJ16259685 (500nM, immediately post-training, ic), or the IP(3)R antagonist Xestospongin C (5microM, immediately post-training, ic), impaired retention from 90min post-training. These findings are consistent with mGluR1 activating IP(3)Rs to release intracellular Ca(2+) required for long-term memory formation and have been interpreted within an LTP2 model. The consequences of different patterns of retention loss following ryanodine receptor (RyR) and IP(3)R inhibition are discussed.

Author information

Author/s: Baker, K D (KD); Edwards, T M (TM); Rickard, N S (NS);

Affiliation: School of Psychology, Psychiatry and Psychological Medicine, Monash University, Clayton, 3800 Vic., Australia. Kathryn.Baker(-atsign-)med.monash.edu.au

Journal and publication information

Publication Type: Journal Article

Journal: Neurobiology of learning and memory (Neurobiol Learn Mem), published in United States. (Language: eng)

Reference: 2008-Jul; vol 90 (issue 1) : pp 269-74

Dates: Created 2008/06/10; Completed 2008/09/03;

PMID: 18495503, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Age Factors
Animals
Avoidance Learning - drug effects; physiology
Calcium - metabolism
Chickens
Dose-Response Relationship, Drug
Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors; metabolism

Inositol 1,4,5-Trisphosphate Receptors - antagonists & inhibitors; metabolism
Long-Term Potentiation - drug effects; physiology
Macrocyclic Compounds - pharmacology
Memory - drug effects; physiology
Oxazoles - pharmacology
Quinolines - pharmacology
Receptors, Metabotropic Glutamate - antagonists & inhibitors; metabolism

Associated Chemicals: (3,4-dihydro-2H-pyrano(2,3)b-quinolin-7-yl)-(cis-4-methoxycyclohexyl) methanone (0) ; Inositol 1,4,5-Trisphosphate Receptors (0) ; Macrocyclic Compounds (0) ; Oxazoles (0) ; Quinolines (0) ; Receptors, Metabotropic Glutamate (0) ; metabotropic glutamate receptor type 1 (0) ; xestospongin C (0) ; Calcium (7440-70-2)

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