Research article summary (published 5 Jul 2008):

Synthesis of enantiomerically pure 1,2,3,4-tetrahydro-beta-carbolines and N-acyl-1-aryl ethylamines by rhodium-catalyzed hydrogenation.

Full Abstract

The rhodium-catalyzed asymmetric hydrogenation of different enamides, in particular, dihydro-beta-carboline derivates, was investigated in the presence of chiral phosphorus ligands. Enantioselectivities of up to 99 % ee were obtained after ligand screening and optimization of the reaction conditions. The scope and limitation of the catalysts were shown in the synthesis of optically active tetrahydro-beta-carbolines and other benchmark N-acyl-1-aryl ethylamines.

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Author information

Author/s: Enthaler, Stephan (S); Erre, Giulia (G); Junge, Kathrin (K); Addis, Daniele (D); Kadyrov, Renat (R); Beller, Matthias (M);

Affiliation: Leibniz-Institut für Katalyse an der Universität Rostock e. V. Albert-Einstein-Str. 29A, D-18059 Rostock, Germany.

Journal and publication information

Publication Type: Journal Article

Journal: Chemistry, an Asian journal (Chem Asian J), published in Germany. (Language: eng)

Reference: 2008-Jul; vol 3 (issue 7) : pp 1104-10

Dates: Created 2008/06/30; Completed 2008/08/13;

PMID: 18496827, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Carbolines - chemical synthesis Catalysis Ethylamines - chemical synthesis Hydrogenation

Hydrogenation Ligands Rhodium Stereoisomerism

Associated Chemicals: Carbolines (0) ; Ethylamines (0) ; Ligands (0) ; Rhodium (7440-16-6)

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