Advanced oxidation protein products (AOPPs) in juvenile overweight and obesity prior to and following weight reduction.

Full Abstract

OBJECTIVES:
To evaluate the formation of advanced oxidation protein products (AOPPs) in juvenile overweight/obesity and obesity-related disorders and to investigate the effect of weight reduction on AOPPs.

DESIGN AND METHODS:
AOPPs were determined in 114 overweight/obese children and adolescents without/with insulin resistance and metabolic syndrome and compared with 53 lean controls. Measurements were repeated following weight reduction program (diet/exercise, bran-enriched diet/exercise, and diet/exercise plus metformin).

RESULTS:
Overweight/obese subjects had higher AOPPs than lean controls, more elevated in patients with co-occurring metabolic syndrome. AOPPs positively correlated with central obesity, triglycerides, lipid peroxidation and insulin, and negatively with glucose to insulin ratio. AOPPs decreased following obesity intervention and DeltaAOPPs correlated with DeltaBMI%. AOPPs reduction was more pronounced in subjects on bran-enriched diet. Baseline AOPPs were a better predictor of clinically significant weight reduction than BMI%.

CONCLUSIONS:
Juvenile overweight/obesity was associated with AOPPs accumulation, more pronounced in metabolic syndrome. Body mass reduction decreased oxidative stress, with bran-enriched diet being more effective than diet/exercise alone.

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Author information

Author/s: Krzystek-Korpacka, Malgorzata (M); Patryn, Eliza (E); Boehm, Dorota (D); Berdowska, Izabela (I); Zielinski, Bogdan (B); Noczynska, Anna (A);

Affiliation: Department of Medical Biochemistry, Wroclaw Medical University, Wroclaw, Poland. krzystek(-atsign-)bioch.am.wroc.pl

Journal and publication information

Publication Type: Journal Article

Journal: Clinical biochemistry (Clin Biochem), published in United States. (Language: eng)

Reference: 2008-Aug; vol 41 (issue 12) : pp 943-9

Dates: Created 2008/07/21; Completed 2008/08/20;

PMID: 18501708, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Analysis of Variance
Blood Glucose - metabolism
Blood Proteins - metabolism
Body Mass Index
Cholesterol - blood
Female
Humans
Insulin - blood
Male

Male
Metabolic Syndrome X - metabolism
Obesity - diet therapy; metabolism
Overweight - diet therapy; metabolism
Oxidation-Reduction
Oxidative Stress
Regression Analysis
Thiobarbituric Acid Reactive Substances - metabolism
Triglycerides - blood
Weight Loss

Associated Chemicals: Blood Glucose (0) ; Blood Proteins (0) ; Thiobarbituric Acid Reactive Substances (0) ; Triglycerides (0) ; Insulin (11061-68-0) ; Cholesterol (57-88-5)

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