Successful pregnancy in a hemodialysis patient and marked resolution of her nephrogenic systemic fibrosis.

Full Abstract

Nephrogenic systemic fibrosis (NSF) is a recently recognized clinicopathologic entity. It is believed to be related to exposure to gadolinium-containing magnetic resonance imaging agents with gadolinium deposition in the tissues, including skin and other organs. It mainly affects patients on dialysis therapy. Pregnancy in dialysis patients is a rare occurrence. We present a case of a dialysis patient who developed NSF after exposure to gadodiamide and went on to have a successful pregnancy while on hemodialysis therapy. The patient had marked clinical and histological improvement in NSF during and after her pregnancy. This also correlated with decreasing gadolinium levels in skin biopsy tissue specimens. We discuss the interplay of factors involved in the successful pregnancy and improvement in NSF lesions in this patient.

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Author information

Author/s: Khurana, Anand (A); Nickel, Allan E (AE); Greene, John F (JF); Narayanan, Mohanram (M); High, Whitney A (WA); Foulks, Charles J (CJ);

Affiliation: Department of Nephrology, Scott & White Clinic, Texas A&M University, Temple, TX 76508, USA. anandkhurana(-atsign-)yahoo.com

Journal and publication information

Publication Type: Journal Article

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation (Am J Kidney Dis), published in United States. (Language: eng)

Reference: 2008-Jun; vol 51 (issue 6) : pp e29-32

Dates: Created 2008/05/26; Completed 2008/07/29;

PMID: 18501778, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Female
Fibrosis - etiology
Humans
Kidney Diseases - complications; therapy

Kidney Diseases - complications; therapy
Pregnancy
Remission Induction
Renal Dialysis
Skin - pathology

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