 |
| Research article summary (published 26 May 2008): |
Dissociating the role of the orbitofrontal cortex and the striatum in the computation of goal values and prediction errors.
Full Abstract
To make sound economic decisions, the brain needs to compute several different value-related signals. These include goal values that measure the predicted reward that results from the outcome generated by each of the actions under consideration, decision values that measure the net value of taking the different actions, and prediction errors that measure deviations from individuals' previous reward expectations. We used functional magnetic resonance imaging and a novel decision-making paradigm to dissociate the neural basis of these three computations. Our results show that they are supported by different neural substrates:
goal values are correlated with activity in the medial orbitofrontal cortex, decision values are correlated with activity in the central orbitofrontal cortex, and prediction errors are correlated with activity in the ventral striatum.
Learn Faster Today Improve your study skills
Author information
Author/s: Hare, Todd A (TA); O'Doherty, John (J); Camerer, Colin F (CF); Schultz, Wolfram (W); Rangel, Antonio (A);
Affiliation: Division of Humanities and Social Sciences, California Institute of Technology, Pasadena, California 91125, USA.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)
Reference: 2008-May; vol 28 (issue 22) : pp 5623-30
Dates: Created 2008/05/29; Completed 2008/07/01;
PMID: 18509023, status: MEDLINE (last retrieval date: 11/6/2008)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
External Links for this article (including full text providers, if available):
Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.
This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.
MeSH headings (categories)
This article was linked to the MESH Headings shown below.
|
|
Related articles
These are the highest related articles currently in the database:
- Neural coding of reward-prediction error signals during classical conditioning with attractive faces.
13 Feb 2007 - Expected value, reward outcome, and temporal difference error representations in a probabilistic decision task.
20 Jun 2007 - Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. 12 Nov 2007
- Primate orbitofrontal cortex and adaptive behaviour. 25 Dec 2005
- Human neural learning depends on reward prediction errors in the blocking paradigm. 26 Sep 2005
- Heterarchical reinforcement-learning model for integration of multiple cortico-striatal loops: fMRI examination in stimulus-action-reward association learning. 18 Sep 2006
- Lights, camembert, action! The role of human orbitofrontal cortex in encoding stimuli, rewards, and choices. 11 Sep 2007
- The role of the human orbitofrontal cortex in taste and flavor processing. 8 Sep 2007
- Choice, uncertainty and value in prefrontal and cingulate cortex. 24 Mar 2008
- Orbitofrontal cortex encodes willingness to pay in everyday economic transactions. 10 Sep 2007
Related Article Map
9/26/2005
3/24/2008
Higher Relevance Score (336/1000)
Lower Relevance Score (303/1000)
Legend: - FREE Full text Article. - Abstract only. 
- Title only. More help.
See a large map of 100+ related articles.