Dissociating the roles of dorsal and ventral CA1 for the temporal processing of spatial locations, visual objects, and odors.

Full Abstract

The differential contributions of the dorsal and ventral hippocampus for learning and memory have long been of interest. The present experiments were designed to evaluate the contributions of dorsal CA1 and ventral CA1 for temporal processing. Animals were run on three temporal ordering paradigms:
one with visual objects, one with olfactory stimuli, and one with spatial locations. Animals with lesions to dorsal CA1 showed deficits for the temporal ordering of visual objects relative to control animals, and deficits for the temporal ordering of spatial locations relative to control and ventral CA1 lesioned animals. Animals with lesions to ventral CA1 showed deficits for the temporal ordering of olfactory information relative to control and dorsal CA1 lesioned animals, and a mild deficit for the temporal ordering of visual objects relative to control animals, but not as severe as those shown by the dorsal CA1 lesioned animals. These data suggest that dorsal CA1 and ventral CA1 contribute to temporal ordering processes, and that dorsal CA1 and ventral CA1 are dissociable for temporal ordering based upon the nature of the information that is processed.(Copyright) 2008 APA, all rights reserved.

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Author information

Author/s: Hunsaker, Michael R (MR); Fieldsted, Paige M (PM); Rosenberg, Jenna S (JS); Kesner, Raymond P (RP);

Affiliation: Department of Psychology, University of Utah, 380 South 1530 East, Room 502, Salt Lake City, UT 84112, USA.

Grants: R01 MH065314 (Agency:United States NIMH)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)

Reference: 2008-Jun; vol 122 (issue 3) : pp 643-50

Dates: Created 2008/06/02; Completed 2008/08/13;

PMID: 18513134, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
Animals
Behavior, Animal
Brain Mapping
Exploratory Behavior - physiology
Hippocampus - anatomy & histology; injuries; pathology
Memory, Short-Term - physiology

Odors
Pattern Recognition, Visual - physiology
Photic Stimulation - methods
Rats
Rats, Long-Evans
Space Perception - physiology
Time Perception - physiology

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