Research article summary (published 30 May 2008):

Involvement of the retrosplenial cortex in processing multiple conditioned stimuli.

Full Abstract

Lesions of retrosplenial cortex (RSP) disrupt spatial and contextual learning, suggesting that RSP may have a fundamental role in processing overlapping, or simultaneously presented stimuli. If so, then RSP lesions might also be expected to disrupt learning that requires the concurrent processing of phasic conditioned stimuli. In Experiment 1, rats were trained in a compound feature negative discrimination task in which a tone was presented and immediately followed by food on some trials, while on other trials a visual stimulus was simultaneously presented along with the tone and not reinforced. Normal rats learned to discriminate between the trials but RSP-lesioned rats exhibited low levels of conditioning on both types of trials. Experiment 2 demonstrated that this effect was not simply due to a general inability to form associations, since RSP-lesioned rats exhibited normal responding when the visual stimulus was presented alone and paired with food. These findings support the view that RSP has an important role in learning that involves the processing of simultaneously presented stimuli and have implications for understanding the functional relationship between the hippocampus and RSP.(Copyright) 2008 APA, all rights reserved.

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Author information

Author/s: Keene, Christopher S (CS); Bucci, David J (DJ);

Affiliation: Dartmouth College, Department of Psychological and Brain Sciences, 6207 Moore Hall, Hanover, NH 03755, USA.

Journal and publication information

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Behavioral neuroscience (Behav Neurosci), published in United States. (Language: eng)

Reference: 2008-Jun; vol 122 (issue 3) : pp 651-8

Dates: Created 2008/06/02; Completed 2008/08/13;

PMID: 18513135, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Appetitive Behavior Association Learning - physiology Avoidance Learning - physiology Behavior, Animal - physiology Conditioning (Psychology) - physiology Discrimination (Psychology) - physiology

Male Photic Stimulation - methods Rats Rats, Long-Evans Reward Spatial Behavior - physiology Temporal Lobe - injuries; physiology

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