Index-based dietary patterns and risk of colorectal cancer: the NIH-AARP Diet and Health Study.

Full Abstract

The authors compared how four indexes-the Healthy Eating Index-2005, Alternate Healthy Eating Index, Mediterranean Diet Score, and Recommended Food Score-are associated with colorectal cancer in the National Institutes of Health-AARP Diet and Health Study (n = 492,382). To calculate each score, they merged data from a 124-item food frequency questionnaire completed at study entry (1995-1996) with the MyPyramid Equivalents Database (version 1.0). Other variables included energy, nutrients, multivitamins, and alcohol. Models were stratified by sex and adjusted for age, ethnicity, education, body mass index, smoking, physical activity, and menopausal hormone therapy (in women). During 5 years of follow-up, 3,110 incident colorectal cancer cases were ascertained. Although the indexes differ in design, a similarly decreased risk of colorectal cancer was observed across all indexes for men when comparing the highest scores with the lowest:
Healthy Eating Index-2005 (relative risk (RR) = 0.72, 95% confidence interval (CI):
0.62, 0.83); Alternate Healthy Eating Index (RR = 0.70, 95%

CI:
0.61, 0.81); Mediterranean Diet Score (RR = 0.72, 95%

CI:
0.63, 0.83); and Recommended Food Score (RR = 0.75, 95%

CI:
0.65, 0.87). For women, a significantly decreased risk was found with the Healthy Eating Index-2005, although Alternate Healthy Eating Index results were similar. Index-based dietary patterns that are consistent with given dietary guidelines are associated with reduced risk.

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Author information

Author/s: Reedy, J (J); Mitrou, P N (PN); Krebs-Smith, S M (SM); Wirfält, E (E); Flood, A (A); Kipnis, V (V); Leitzmann, M (M); Mouw, T (T); Hollenbeck, A (A); Schatzkin, A (A); Subar, A F (AF);

Affiliation: Risk Factor Monitoring and Methods Branch, Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD 20892-7344, USA. reedyj(-atsign-)mail.nih.gov

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Intramural

Journal: American journal of epidemiology (Am J Epidemiol), published in United States. (Language: eng)

Reference: 2008-Jul; vol 168 (issue 1) : pp 38-48

Dates: Created 2008/06/20; Completed 2008/07/03;

PMID: 18525082, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged
Colorectal Neoplasms - epidemiology; etiology
Confidence Intervals
Diet - classification; statistics & numerical data
Diet Surveys
Diet, Mediterranean - statistics & numerical data
Female
Health Surveys

Health Surveys
Humans
Life Style
Male
Middle Aged
Questionnaires
Risk Factors
United States - epidemiology

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