Aging and disease as modifiers of efficacy of cell therapy.

Full Abstract

Cell therapy is a promising option for treating ischemic diseases and heart failure. Adult stem and progenitor cells from various sources have experimentally been shown to augment the functional recovery after ischemia, and clinical trials have confirmed that autologous cell therapy using bone marrow-derived or circulating blood-derived progenitor cells is safe and provides beneficial effects. However, aging and risk factors for coronary artery disease affect the functional activity of the endogenous stem/progenitor cell pools, thereby at least partially limiting the therapeutic potential of the applied cells. In addition, age and disease affect the tissue environment, in which the cells are infused or injected. The present review article will summarize current evidence for cell impairment during aging and disease but also discuss novel approaches how to reverse the dysfunction of cells or to refresh the target tissue. Pretreatment of cells or the target tissue by small molecules, polymers, growth factors, or a combination thereof may provide useful approaches for enhancement of cell therapy for cardiovascular diseases.

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Author information

Author/s: Dimmeler, Stefanie (S); Leri, Annarosa (A);

Affiliation: Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Dimmeler(-atsign-)em.uni-frankfurt.de

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Circulation research (Circ Res), published in United States. (Language: eng)

Reference: 2008-Jun; vol 102 (issue 11) : pp 1319-30

Dates: Created 2008/06/06; Completed 2008/06/12;

PMID: 18535269, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Stem Cells - drug effects; transplantation
Aging
Animals
Cell Aging - drug effects
Heart Diseases - physiopathology; therapy

Humans
Intercellular Signaling Peptides and Proteins - pharmacology
Risk Factors
Stem Cell Transplantation - methods
Treatment Outcome

Associated Chemicals: Intercellular Signaling Peptides and Proteins (0)

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