Food group intake and risk of subtypes of esophageal and gastric cancer.

Full Abstract

Incidence rates for adenocarcinomas of the esophagus and gastric cardia have been increasing rapidly, while rates for non-cardia gastric adenocarcinoma and esophageal squamous cell carcinoma have declined. We examined food group intake as a risk factor for subtypes of esophageal and gastric cancers in a multicenter, population-based case-control study in Connecticut, New Jersey and western Washington state. Associations between food groups and risk were estimated using adjusted odds ratios (OR), based on increasing intake of one serving per day. Total vegetable intake was associated with decreased risk of esophageal adenocarcinoma (OR = 0.85, 95% CI = 0.75, 0.96). Conversely, total meat intake was associated with increased risk of esophageal adenocarcinoma (OR = 1.43, 95% CI = 1.11, 1.83), gastric cardia adenocarcinoma (OR = 1.37, 95% CI = 1.08, 1.73) and noncardia gastric adenocarcinoma (OR = 1.39, 95% CI = 1.12, 1.71), with red meat most strongly associated with esophageal adenocarcinoma risk (OR = 2.49, 95% CI = 1.39, 4.46). Poultry was most strongly associated with gastric cardia adenocarcinoma (OR = 1.89, 95% CI = 1.15, 3.11) and noncardia gastric adenocarcinoma (OR = 1.90, 95% CI = 1.19, 3.03). High-fat dairy was associated with increased risk of both esophageal and gastric cardia adenocarcinoma. Higher intake of meats, particularly red meats, and lower intake of vegetables were associated with an increased risk of esophageal adenocarcinoma, while higher intake of meats, particularly poultry, and high-fat dairy was associated with increased risk of gastric cardia adenocarcinoma.(c) 2008 Wiley-Liss, Inc.

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Author information

Author/s: Navarro Silvera, Stephanie A (SA); Mayne, Susan T (ST); Risch, Harvey (H); Gammon, Marilee D (MD); Vaughan, Thomas L (TL); Chow, Wong-Ho (WH); Dubrow, Robert (R); Schoenberg, Janet B (JB); Stanford, Janet L (JL); West, A Brian (AB); Rotterdam, Heidrun (H); Blot, William J (WJ); Fraumeni, Joseph F (JF);

Affiliation: Department of Health and Nutrition Sciences, Montclair State University, Montclair, NJ 07043, USA. silveras(-atsign-)mail.montclair.edu

Grants: N01-CN05230 (Agency:United States NCI) ; N02-CP40501 (Agency:United States NCI) ; U01-CA57923 (Agency:United States NCI) ; U01-CA57949 (Agency:United States NCI) ; U01-CA57983 (Agency:United States NCI)

Journal and publication information

Publication Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural

Journal: International journal of cancer. Journal international du cancer (Int J Cancer), published in United States. (Language: eng)

Reference: 2008-Aug; vol 123 (issue 4) : pp 852-60

Dates: Created 2008/06/23; Completed 2008/07/15;

PMID: 18537156, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adenocarcinoma - epidemiology
Adult
Aged
Carcinoma, Squamous Cell - epidemiology
Cardia - pathology
Case-Control Studies
Diet
Esophageal Neoplasms - epidemiology
Female

Female
Fruit
Humans
Male
Meat
Middle Aged
Stomach Neoplasms - epidemiology
United States - epidemiology
Vegetables

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