A structural genomics approach to the regulation of apoptosis: chimp vs. human.

Full Abstract

After the sequencing of the human genome, the publication of the genome of our nearest relative, the chimpanzee (Pan troglodytes) provided groundbreaking data improving the understanding of the recent human evolution. There are about forty million changes, most of them single nucleotide substitutions, which teach us about ourselves, both in terms of similarities and differences with chimpanzees. From a medical point of view differences in incidence and severity of diseases are of special importance to pinpoint novel targets and to develop innovative therapies. This analysis focuses on the cognition that chimpanzees rarely suffer from cancer. To elucidate possible reasons for this finding, we compare differences regarding apoptosis and DNA-repair on different levels of chromosome organization, gene structure, post-transcriptional and post-translational modifications to functional changes in protein structures. The result is a complex pattern of subtle variances and a few large-scale changes.

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Author information

Author/s: Ahmed, Jessica (J); Günther, Stefan (S); Möller, Friedrich (F); Preissner, Robert (R);

Affiliation: Institute of Molecular Biology and Bioinformatics, Charite-University Medicine Berlin, Arnimallee 22, 14195 Berlin, Germany. jessica.ahmed(-atsign-)charite.de

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Genome informatics. International Conference on Genome Informatics (Genome Inform), published in Japan. (Language: eng)

Reference: 2007-; vol 18 (issue ) : pp 22-34

Dates: Created 2008/06/11; Completed 2008/08/05;

PMID: 18546471, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals
Apoptosis - genetics
Genomics
Humans - genetics

Humans - genetics
Pan troglodytes - genetics
Protein Processing, Post-Translational
RNA Processing, Post-Transcriptional

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