SAPHIR: a physiome core model of body fluid homeostasis and blood pressure regulation.

Full Abstract

We present the current state of the development of the SAPHIR project (a Systems Approach for PHysiological Integration of Renal, cardiac and respiratory function). The aim is to provide an open-source multi-resolution modelling environment that will permit, at a practical level, a plug-and-play construction of integrated systems models using lumped-parameter components at the organ/tissue level while also allowing focus on cellular- or molecular-level detailed sub-models embedded in the larger core model. Thus, an in silico exploration of gene-to-organ-to-organism scenarios will be possible, while keeping computation time manageable. As a first prototype implementation in this environment, we describe a core model of human physiology targeting the short- and long-term regulation of blood pressure, body fluids and homeostasis of the major solutes. In tandem with the development of the core models, the project involves database implementation and ontology development.

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Author information

Author/s: Thomas, S Randall (SR); Baconnier, Pierre (P); Fontecave, Julie (J); Françoise, Jean-Pierre (JP); Guillaud, François (F); Hannaert, Patrick (P); Hernández, Alfredo (A); Le Rolle, Virginie (V); Mazière, Pierre (P); Tahi, Fariza (F); White, Ronald J (RJ);

Affiliation: Informatics, Integrative Biology, and Complex Systems, FRE CNRS 3190, Evry 91000, France. srthomas(-atsign-)ibisc.fr

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal: Philosophical transactions. Series A, Mathematical, physical, and engineering sciences (Philos Transact A Math Phys Eng Sci), published in England. (Language: eng)

Reference: 2008-Sep; vol 366 (issue 1878) : pp 3175-97

Dates: Created 2008/07/28; Completed 2008/09/30;

PMID: 18565814, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acid-Base Equilibrium - physiology
Blood Pressure - physiology
Body Fluids - physiology
Computer Simulation
Homeostasis
Humans

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