Genetic enhancement of stem cell engraftment, survival, and efficacy.

Full Abstract

Cell-based therapies for the prevention and treatment of cardiac dysfunction offer the potential to significantly modulate cardiac function and improve outcomes in patients with cardiovascular disease. To date several clinical studies have suggested the potential efficacy of several different stem cell types; however, the benefits seen in clinical trials have been inconsistent and modest. In parallel, preclinical studies have identified key events in the process of cell-based myocardial repair, including stem cell homing, engraftment, survival, paracrine factor release, and differentiation that need to be optimized to maximize cardiac repair and function. The inconsistent and modest benefits seen in clinical trials combined with the preclinical identification of mediators responsible for key events in cell-based cardiac repair offers the potential for cell-based therapy to advance to cell-based gene therapy in an attempt to optimize these key events in the hope of maximizing clinical benefit. Below we discuss potential key events in cardiac repair and the mediators of these events that could be of potential interest for genetic enhancement of stem cell-based cardiac repair.

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Author information

Author/s: Penn, Marc S (MS); Mangi, Abeel A (AA);

Affiliation: Skirball Laboratory for Cardiovascular Cellular Therapeutics, Center for Cardiovascular Cellular Therapeutics, NE3, 9500 Euclid Avenue, Cleveland, OH 44195, USA. pennm(-atsign-)ccf.org

Grants: HL74400 (Agency:United States NHLBI) ; HL84142 (Agency:United States NHLBI)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

Journal: Circulation research (Circ Res), published in United States. (Language: eng)

Reference: 2008-Jun; vol 102 (issue 12) : pp 1471-82

Dates: Created 2008/06/20; Completed 2008/07/31;

PMID: 18566313, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Cell Communication
Cell Movement
Cell Survival
Chemokines - genetics; physiology; therapeutic use
Endothelial Cells - transplantation
Endothelium, Vascular - injuries
Extracellular Matrix - physiology
Gene Therapy
Gene Transfer Techniques
Genetic Vectors - physiology
Graft Enhancement, Immunologic

Graft Enhancement, Immunologic
Heart - physiology
Heart Diseases - surgery
Humans
Integrins - physiology
Intercellular Signaling Peptides and Proteins - genetics; physiology; therapeutic use
Myocytes, Cardiac - physiology
Neovascularization, Physiologic
Recombinant Proteins - therapeutic use
Regeneration
Stem Cell Transplantation

Associated Chemicals: Chemokines (0) ; Integrins (0) ; Intercellular Signaling Peptides and Proteins (0) ; Recombinant Proteins (0)

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