Research article summary (published 29 Jun 2008):

Evaluation of the Addenbrooke's Cognitive Examination's validity in a brain injury rehabilitation setting.

Full Abstract

BACKGROUND: Several reports have warned of the Mini Mental State Examination's (MMSE) inability to detect gross memory and high executive impairments. Addenbrooke's Cognitive Examination-Revised (ACE-R) has gained enormous popularity in dementia screening as it addresses the main shortcomings of MMSE. Aim: This study aimed at evaluating the use of ACE-R and to establish its sensitivity compared to MMSE in a cohort of brain injury patients. METHOD: ACE-R was administered to a cohort of chronic brain injury patients. All patients had a cognitive impairment which was severe enough to prevent them working or studying. Patients with significant mental health, sensory, communication or physical impairments were excluded. RESULTS: Thirty-six patients were recruited, 31 males with a mean age of 37 years. For an upper cut-off value of 27/30 for MMSE and 88/100 for ACE-R, their sensitivities were 36% and 72%, respectively. For a lower cut-off value of 24/30 and 82/100 the tests sensitivities were 11% and 56%, respectively. Analysis of the ACE-R sub-tests indicated that memory and verbal fluency sub-tests showed the most dramatic impairment. CONCLUSION: MMSE is insensitive as a screening test in brain injury patients. The results show ACE-R to be a sensitive, easily administered test.

Author information

Author/s: Gaber, Tarek A-Z K (TA);

Affiliation: Wrightington, Wigan and Leigh NHS Trust, UK. tgaber(-atsign-)doctors.net.uk

Journal and publication information

Publication Type: Evaluation Studies; Journal Article

Journal: Brain injury : [BI] (Brain Inj), published in England. (Language: eng)

Reference: 2008-Jul; vol 22 (issue 7-8) : pp 589-93

Dates: Created 2008/06/23; Completed 2008/12/05; Revised 2009/01/02;

PMID: 18568712, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult Brain Injuries - psychology; rehabilitation Cognition Disorders - diagnosis Cohort Studies Female Humans

Humans Male Middle Aged Neuropsychological Tests - standards Psychiatric Status Rating Scales Sensitivity and Specificity

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