Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women.

Full Abstract

BACKGROUND:
The impact of overall dietary patterns that reflect actual eating behaviors on mortality caused by cardiovascular or other chronic diseases is largely unknown.

METHODS AND RESULTS:
We prospectively evaluated the relation between dietary patterns and risk of cardiovascular, cancer, and all-cause mortality among 72,113 women who were free of myocardial infarction, angina, coronary artery surgery, stroke, diabetes mellitus, or cancer and were followed up from 1984 to 2002. Dietary patterns were derived by factor analysis based on validated food frequency questionnaires administered every 2 to 4 years. Two major dietary patterns were identified:
High prudent pattern scores represented high intakes of vegetables, fruit, legumes, fish, poultry, and whole grains, whereas high Western pattern scores reflected high intakes of red meat, processed meat, refined grains, french fries, and sweets/desserts. During 18 years of follow-up, 6011 deaths occurred, including 1154 cardiovascular deaths and 3139 cancer deaths. After multivariable adjustment, the prudent diet was associated with a 28% lower risk of cardiovascular mortality (95% confidence interval [CI], 13 to 40) and a 17% lower risk of all-cause mortality (95% CI, 10 to 24) when the highest quintile was compared with the lowest quintile. In contrast, the Western pattern was associated with a higher risk of mortality from cardiovascular disease (22%; 95% CI, 1 to 48), cancer (16%; 95% CI, 3 to 30), and all causes (21%; 95% CI, 12 to 32).

CONCLUSIONS:
Greater adherence to the prudent pattern may reduce the risk of cardiovascular and total mortality, whereas greater adherence to the Western pattern may increase the risk among initially healthy women.

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Author information

Author/s: Heidemann, Christin (C); Schulze, Matthias B (MB); Franco, Oscar H (OH); van Dam, Rob M (RM); Mantzoros, Christos S (CS); Hu, Frank B (FB);

Affiliation: Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02215, USA.

Grants: CA87969 (Agency:United States NCI) ; CA95589 (Agency:United States NCI) ; HL60712 (Agency:United States NHLBI)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Circulation (Circulation), published in United States. (Language: eng)

Reference: 2008-Jul; vol 118 (issue 3) : pp 230-7

Dates: Created 2008/07/15; Completed 2008/08/13;

PMID: 18574045, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

Comments and Corrections

CommentIn: Circulation. 2008 Jul 15;118(3):214-5. (PMID: 18625902)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Cardiovascular Diseases - mortality
Chronic Disease - mortality
Cohort Studies
Diet
Factor Analysis, Statistical
Female
Humans

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