Epidemiology of cytokines: the Women On the Move through Activity and Nutrition (WOMAN) Study.

Full Abstract

Using multiplex technology, the authors investigated the laboratory and biologic variation of a panel of cytokines (interleukin (IL)-1a, IL-1 receptor antagonist, IL-4, IL-6, IL-8, IL-10, interferon-inducible protein-10, monocyte chemoattractant protein-1, and tumor necrosis factor-alpha) over 18 months and their relations to cardiovascular disease risk factors, hormone therapy, and weight loss. Data were obtained from the Woman On the Move through Activity and Nutrition (WOMAN) Study, a randomized clinical trial investigating the effect of nonpharmacologic interventions on subclinical atherosclerosis among overweight, postmenopausal women in Pennsylvania. The present analysis (February 2002-August 2005) comprised 290 women aged 52-62 years (mean age = 57 years). Most of the cytokines were detectable in a majority of the samples, and the between-individual biologic variation was greater than the within-individual biologic and laboratory variation. There was little association between use of hormone therapy at baseline or change in hormone therapy by 18 months and cytokine levels. Weight loss was associated with a decrease in levels of IL-1 receptor antagonist, IL-6, and C-reactive protein. The results suggest that a wide panel of cytokines may be measured simultaneously from one sample. There is large unexplained variability in cytokine levels that is probably due to genetic-environmental associations.

Learn Faster Today Improve your study skills

Author information

Author/s: Wong, Eric (E); Freiberg, Matthew (M); Tracy, Russell (R); Kuller, Lewis (L);

Affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA.

Grants: R01-HL-66468 (Agency:United States NHLBI)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal: American journal of epidemiology (Am J Epidemiol), published in United States. (Language: eng)

Reference: 2008-Aug; vol 168 (issue 4) : pp 443-53

Dates: Created 2008/08/11; Completed 2008/08/21;

PMID: 18579536, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article (including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Analysis of Variance
C-Reactive Protein - metabolism
Cardiovascular Diseases - epidemiology; etiology; prevention & control
Chemokine CCL2 - blood
Chemokine CXCL10 - blood
Cytokines - blood; immunology
Estrogen Replacement Therapy - adverse effects
Female
Humans
Inflammation
Interleukin-1 - blood
Interleukin-10 - blood
Interleukin-1alpha - blood
Interleukin-4 - blood
Interleukin-6 - blood

Interleukin-8 - blood
Linear Models
Middle Aged
Obesity - blood; complications; immunology; prevention & control
Pennsylvania - epidemiology
Postmenopause - blood; immunology
Prospective Studies
Proteomics
Randomized Controlled Trials as Topic
Receptors, Interleukin-1 - antagonists & inhibitors
Risk Assessment
Statistics, Nonparametric
Tumor Necrosis Factor-alpha - blood
Weight Loss - physiology
Women's Health

Associated Chemicals: Chemokine CCL2 (0) ; Chemokine CXCL10 (0) ; Cytokines (0) ; Interleukin-1 (0) ; Interleukin-1alpha (0) ; Interleukin-6 (0) ; Interleukin-8 (0) ; Receptors, Interleukin-1 (0) ; Tumor Necrosis Factor-alpha (0) ; Interleukin-10 (130068-27-8) ; Interleukin-4 (207137-56-2) ; C-Reactive Protein (9007-41-4)

These are the highest related articles currently in the database:

See 100+ related articles.