Research article summary (published 12 Jun 2008):

Antidepressant-like effects of intracerebroventricular FGF2 in rats.

Full Abstract

The fibroblast growth factor (FGF) system is altered in post-mortem brains of individuals with major depressive disorder (MDD), but the functional relevance of this observation remains to be elucidated. To this end, we tested whether administering agents that act on FGF receptors would have antidepressant-like effects in rodents. We microinjected either FGF2 (200 ng, i.c.v.) or the FG loop (FGL) of neural cell adhesion molecule (NCAM) (5 microg, i.c.v.) into the lateral ventricle of rats and tested them on the forced swim test. Activating FGF receptors acutely had an antidepressant-like effect in the forced swim test. Furthermore, chronic FGF2 decreased depression-like behavior as assessed by two independent tests. Finally, the FGF system itself was altered after FGF2 administration. Specifically, there was an increase in FGFR1 mRNA in the dentate gyrus 24 h post-FGF2, suggesting the potential for self-amplification of the initial signal. These results support the potential therapeutic use of FGF2 or related molecules in the treatment of MDD and point to alternate mechanisms of neuronal remodeling that may be critical in this treatment.

Author information

Author/s: Turner, Cortney A (CA); Gula, Edny L (EL); Taylor, Larry P (LP); Watson, Stanley J (SJ); Akil, Huda (H);

Affiliation: 205 Zina Pitcher Place, Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA. caturner(-atsign-)umich.edu

Grants: DA007267 (Agency:NIDA NIH HHS) ; DA007268 (Agency:NIDA NIH HHS) ; DA021633 (Agency:NIDA NIH HHS) ; MH042251 (Agency:NIMH NIH HHS) ; MH060398 (Agency:NIMH NIH HHS) ; P01 DA021633-01A2 (Agency:NIDA NIH HHS) ; P01 DA021633-02 (Agency:NIDA NIH HHS) ; P01 MH042251-160013 (Agency:NIMH NIH HHS) ; P50 MH060398-070003 (Agency:NIMH NIH HHS) ; P50 MH060398-080003 (Agency:NIMH NIH HHS) ; P50 MH060398-090003 (Agency:NIMH NIH HHS) ; T32 DA007267-14 (Agency:NIDA NIH HHS) ; T32 DA007268-13 (Agency:NIDA NIH HHS)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Brain research (Brain Res), published in Netherlands. (Language: eng)

Reference: 2008-Aug; vol 1224 (issue ) : pp 63-8

Dates: Created 2008/07/28; Completed 2008/10/30; Revised 2009/08/13;

PMID: 18586016, status: MEDLINE (last retrieval date: 8/21/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Behavior, Animal - drug effects; physiology Brain - drug effects; metabolism Dentate Gyrus - drug effects; metabolism Depressive Disorder - drug therapy; metabolism; physiopathology Disease Models, Animal Fibroblast Growth Factor 2 - genetics; pharmacology; therapeutic use In Situ Hybridization

Injections, Intraventricular Male Neuropsychological Tests RNA, Messenger - drug effects; metabolism Rats Rats, Sprague-Dawley Receptor, Fibroblast Growth Factor, Type 1 - agonists; genetics; metabolism Stress, Psychological - drug therapy; metabolism; physiopathology

Associated Chemicals: RNA, Messenger (0) ; Fibroblast Growth Factor 2 (103107-01-3) ; Fgfr1 protein, rat (EC 2.7.1.112) ; Receptor, Fibroblast Growth Factor, Type 1 (EC 2.7.1.112)

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