Suppression of glucocorticoid secretion enhances cholinergic transmission in rat hippocampus.

Full Abstract

We previously demonstrated that suppression of glucocorticoid secretion by adrenalectomy (ADX) impaired prefrontal cortex-sensitive working memory, but not reference memory. Since the cholinergic system in the hippocampus is also involved in these memories, we examined the effects of glucocorticoid suppression on cholinergic transmission in the rat hippocampus. A microdialysis study revealed that ADX did not affect the basal acetylcholine release, but enhanced the KCl-evoked response. This enhanced response was reversed by the corticosterone replacement treatment. The extracellular choline concentrations increased under both basal and KCl-stimulated conditions in the ADX rats, and these increases were also reversed by the corticosterone replacement. These results indicate that suppression of glucocorticoid secretion enhances cholinergic transmission in the hippocampus in response to stimuli. It is possible that this enhanced cholinergic transmission may not contribute to the ADX-induced working memory impairment, but it may be involved in maintenance of reference memory.

Author information

Author/s: Mizoguchi, Kazushige (K); Shoji, Hirotaka (H); Ikeda, Ryuji (R); Tanaka, Yayoi (Y); Maruyama, Wakako (W); Tabira, Takeshi (T);

Affiliation: Department of Geriatric Medicine, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36-3 Gengo, Morioka, Obu, Aichi 474-8511, Japan. k-mizo(-atsign-)nils.go.jp

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Brain research bulletin (Brain Res Bull), published in United States. (Language: eng)

Reference: 2008-Aug; vol 76 (issue 6) : pp 612-5

Dates: Created 2008/07/07; Completed 2008/08/19;

PMID: 18598852, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Acetylcholine - analysis; metabolism; secretion
Adrenalectomy - methods
Animals
Anti-Inflammatory Agents - administration & dosage; metabolism; pharmacology
Choline - metabolism
Cholinergic Fibers - drug effects; metabolism
Chromatography, High Pressure Liquid - methods
Corticosterone - administration & dosage; metabolism; pharmacology
Extracellular Space - metabolism
Glucocorticoids - physiology; secretion
Hippocampus - cytology; drug effects; metabolism

Hippocampus - cytology; drug effects; metabolism
Injections, Intraperitoneal
Male
Memory - drug effects; physiology
Microdialysis - methods
Neurons - cytology; drug effects; metabolism
Potassium Chloride - pharmacology
Radioimmunoassay - methods
Rats
Rats, Wistar
Synaptic Transmission - drug effects; physiology

Associated Chemicals: Anti-Inflammatory Agents (0) ; Glucocorticoids (0) ; Corticosterone (50-22-6) ; Acetylcholine (51-84-3) ; Choline (62-49-7) ; Potassium Chloride (7447-40-7)

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