Weight change over three decades and the risk of osteoporosis in men: the Norwegian Epidemiological Osteoporosis Studies (NOREPOS).

Full Abstract

The purpose of this study was to assess the effect of weight in middle-aged men and subsequent weight change on the risk of osteoporosis three decades later. The authors utilized data from 1,476 Norwegian men participating in two health screenings in Oslo (1972-1973 and 2000-2001) and Tromsø (1974-1975 and 2001). Height and weight were measured at baseline and follow-up. Total hip bone mineral density (BMD) was assessed at follow-up by dual energy x-ray absorptiometry. Baseline body mass index (BMI) was positively related to BMD three decades later. Subsequent weight change was also strongly related to BMD, and the proportion of persons with osteoporosis decreased from 15.1% among those who lost >or=10% of their body weight to 0.6% among those who gained >or=10% of their body weight. Excluding participants with medical conditions did not change the association between weight change and BMD. Taking both BMI and weight change into account, the prevalence of osteoporosis in the lowest quarter of baseline BMI was 31% (95% confidence interval:
24, 37) in persons losing >or=5% of their weight and 4% (95% confidence interval:
1, 7) in persons gaining >or=5% of their weight. In this cohort of middle-aged men, low baseline BMI and weight loss during the following three decades were both strongly and negatively related to total hip BMD.

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Author information

Author/s: Meyer, Haakon E (HE); Søgaard, Anne Johanne (AJ); Falch, Jan A (JA); Jørgensen, Lone (L); Emaus, Nina (N);

Affiliation: Section for Preventive Medicine and Epidemiology, Institute of General Practice and Community Medicine, University of Oslo, Oslo, Norway. h.e.meyer(-atsign-)medisin.uio.no

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: American journal of epidemiology (Am J Epidemiol), published in United States. (Language: eng)

Reference: 2008-Aug; vol 168 (issue 4) : pp 454-60

Dates: Created 2008/08/11; Completed 2008/08/21;

PMID: 18599490, status: MEDLINE (last retrieval date: 11/6/2008)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Absorptiometry, Photon
Adult
Aged
Body Mass Index
Bone Density
Confounding Factors (Epidemiology)
Epidemiologic Studies
Exercise
Follow-Up Studies
Hip Fractures - epidemiology; etiology
Humans
Life Style

Linear Models
Male
Mass Screening
Middle Aged
Norway - epidemiology
Osteoporosis - diagnosis; epidemiology; etiology
Population Surveillance
Prevalence
Risk Factors
Smoking - adverse effects; epidemiology
Weight Gain
Weight Loss

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