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| Research article summary (published 3 Apr 2009): |
COMT val158met modulates association between brain white matter architecture and IQ.
Full Abstract
The intelligence quotient (IQ) is typically associated with the architecture of gray and white matter in specific brain regions, and this association appears to be genetically based. However, specific sources of genetic variation for the association have not been studied extensively. Using diffusion tensor imaging in 15 mental retardation patients and 80 healthy volunteers, we studied the association between white matter architecture and IQ and also investigated the effects of COMT val158met on this association. The results showed that fractional anisotropy (FA) values in the prefrontal lobe and the hippocampus formation were associated with IQ and that val158met may affect this association. Subjects who were val homozygous showed steeper slopes for regression of the FA value on IQ than met carriers. Our findings suggest that COMT val158met may contribute to intelligence by affecting the association between IQ and the white matter architecture in the prefrontal lobe and the hippocampal formation. (c) 2008 Wiley-Liss, Inc.
Author information
Author/s: Li, Jun (J); Yu, Chunshui (C); Li, Yonghui (Y); Liu, Bing (B); Liu, Yong (Y); Shu, Ni (N); Song, Ming (M); Zhou, Yuan (Y); Zhu, Wanlin (W); Li, Kuncheng (K); Jiang, Tianzi (T);
Affiliation: National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100190, P.R. China.
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics (Am J Med Genet B Neuropsychiatr Genet), published in United States. (Language: eng)
Reference: 2009-Apr; vol 150B (issue 3) : pp 375-80
Dates: Created 2009/03/24; Completed 2009/05/19;
PMID: 18615479, status: MEDLINE (last retrieval date: 5/19/2009, IMS Date: 19 May 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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