Research article summary:

Capillary electrophoresis of complex natural polysaccharides.

Full Abstract

Complex natural polysaccharides, glycosaminoglycans (GAGs), are a class of ubiquitous macromolecules that exhibit a wide range of biological functions and participate and regulate multiple cellular events and (patho)physiological processes. They are generally present either as free chains (hyaluronic acid and bacterial acidic polysaccharides) or as side chains of proteoglycans (PGs; chondroitin/dermatan sulfate, heparin/heparan sulfate, and keratan sulfate) and are most often found in cell membranes and in the extracellular matrix. The recent emergence of modern analytical tools for their study has produced a virtual explosion in the field of glycomics. CE, due to its high resolving power and sensitivity, has been useful in the analysis of intact GAGs and GAG-derived oligosaccharides and disaccharides affording concentration and structural characterization data essential for understanding the biological functions of GAGs. In this review, novel off-line and on-line CE-MS and MS/MS methods for screening of GAG-derived oligosaccharides and disaccharides will be discussed.

This information was obtained from the public area of Pubmed, part of the National Library of Medicine (NLM). Abstract text and other information may be subject to copyright.

Free Speed Reading Course Free Learning Styles Test Test Your Learning Skills Free

Author information

First Name	LastName	Initials
	Volpi	N
	Maccari	F
	Linhardt	RJ

Affiliation: Department of Biologia Animale, Biological Chemistry Section, University of Modena and Reggio Emilia, Modena, Italy.

Grants:

Journal and publication information

Publication Type: JOURNAL ARTICLE

Journal: Electrophoresis (Electrophoresis).

Reference: 2008-Jul; vol (issue ) : pp

Language: ENG

PMID: 18633943 (status: Publisher) (last retrieval date: 7/19/2008)

External Links for this article (including full text providers, if available):

For links to sites providing the full text of this article and related topics see links. Note there may be a subscription or fee required for access to the full text.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

No MeSH Headings found.

The article may not be MeSH Indexed as yet.

These are the highest related articles currently in the database:

See 100+ related articles.