Gastric pentadecapeptide BPC 157 as an effective therapy for muscle crush injury in the rat.

Full Abstract

PURPOSE: Stable gastric pentadecapeptide BPC 157 accelerates the healing of a transected Achilles tendon and a transected quadriceps muscle. It may also be of clinical relevance as a systemic and local peptide treatment for crush injury of a major muscle, such as gastrocnemius muscle complex. BPC 157 is effective without a carrier, and it is presently undergoing trials for inflammatory bowel disease, and no toxicity has so far been reported. METHODS: In crushed rats (force delivered 0.727 Ns/cm2), BPC 157 was applied either intraperitoneally or locally, as a thin cream layer, immediately after injury (sacrifice at 2 h), and once a day for 14 days. RESULTS: BPC 157 improved muscle healing, macroscopically (less hematoma and edema, no post-injury leg contracture), microscopically, functionally, and also based on enzyme activity (creatine kinase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase). CONCLUSION: BPC 157, at all investigated intervals, given locally or intraperitoneally, accelerated post-injury muscle healing and also helped to restore the full function.

Author information

Author/s: Novinscak, Tomislav (T); Brcic, Luka (L); Staresinic, Mario (M); Jukic, Ivana (I); Radic, Bozo (B); Pevec, Danira (D); Mise, Sandro (S); Tomasovic, Sanja (S); Brcic, Iva (I); Banic, Tihomir (T); Jakir, Ana (A); Buljat, Gojko (G); Anic, Tomislav (T); Zoricic, Ivan (I); Romic, Zeljko (Z); Seiwerth, Sven (S); Sikiric, Predrag (P);

Affiliation: Department of Pharmacology, Institute of Pathology, University of Zagreb Medical School, Salata 11, 10 000, Zagreb, Croatia.

Journal and publication information

Publication Type: Journal Article

Journal: Surgery today (Surg Today), published in Japan. (Language: eng)

Reference: 2008-; vol 38 (issue 8) : pp 716-25

Dates: Created 2008/07/31; Completed 2009/01/27;

PMID: 18668315, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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