Research article summary (published 5 Aug 2008):

Mechanics of muscle injury induced by lengthening contraction.

Full Abstract

Skeletal muscle is composed of two primary structural components, contractile myofibrils and extracellular matrix (ECM). The myofibrils adhere to the surrounding endomysium through the basal lamina, sarcolemma and dystrophin, and dystrophin associated glycoprotein (DAG). In this study, a novel shear lag type model is developed to investigate the mechanics of injury to the single muscle fiber due to lengthening contractions. A single muscle fiber is considered as a composite system with reinforced by the contractile myofibrils. The lateral linkages between myofibril and endomysium is modeled as a zero thickness coating layer, that could be injured under high interfacial shear stress. The results shows that the degree of the muscle injury is correlated to the magnitude of the passive stretch during the contraction. Dystrophic muscles are more susceptible to contraction induced injury due to lack of DAG complex in lateral linkage.

Author information

Author/s: Gao, Yingxin (Y); Wineman, Alan S (AS); Waas, Anthony M (AM);

Affiliation: Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109-2125, USA.

Journal and publication information

Publication Type: Journal Article

Journal: Annals of biomedical engineering (Ann Biomed Eng), published in United States. (Language: eng)

Reference: 2008-Oct; vol 36 (issue 10) : pp 1615-23

Dates: Created 2008/09/10; Completed 2008/10/09;

PMID: 18686034, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Biomechanics Dystrophin-Associated Protein Complex - physiology Extracellular Matrix Proteins - physiology Humans Models, Biological Muscle Contraction

Muscle Stretching Exercises Muscle, Skeletal - injuries; physiopathology Myofibrils - physiology Shear Strength Stress, Mechanical Tensile Strength

Associated Chemicals: Dystrophin-Associated Protein Complex (0) ; Extracellular Matrix Proteins (0)

Related articles

These are the highest related articles currently in the database:

• A muscle contusion injury model. Biomechanics, physiology, and histology. 30 Aug 1994
• The contribution of contractile pre-activation to loss of function after a single lengthening contraction. 29 Jun 2005
• Uncoupling of in vivo torque production from EMG in mouse muscles injured by eccentric contractions. 27 Feb 1999
• Peak power of muscles injured by lengthening contractions. 29 Sep 2006
• Adaptation to lengthening contraction-induced injury in mouse muscle. 28 Apr 2004
• Effects of warm-up before eccentric exercise on indirect markers of muscle damage. 29 Nov 2002
• Effects of therapeutic ultrasound on the regeneration of skeletal myofibers after experimental muscle injury. 30 Dec 1998
• A stochastic model of elbow flexion strength for subjects with and without long head biceps tear. 29 Sep 2005
• Neutrophil accumulation following passive stretches contributes to adaptations that reduce contraction-induced skeletal muscle injury in mice. 12 Feb 2008
• Differential expression of muscle damage in humans following acute fast and slow velocity eccentric exercise. 30 Aug 2005

See 100+ related articles.

Related Article Map

Legend: - FREE Full text Article. - Abstract only. - Title only. More help.

See a large map of 100+ related articles.