[Sirenomelia as a part of VACTERL association: a study of three cases]

(Sirénomélie entrant dans le cadre d'une association VACTERL : à propos de trois cas.)

Full Abstract

Sirenomelia, characterized by a fusion of lower limb buds, is rare. Moreover, the coexistence of this malformation with a VACTERL sequence is exceptional. We report, here, three new observations associating these two diseases on fetuses from 14 to 26 weeks gestation. With these three new cases associating sirenomelia and VACTERL, observed in our unit and examined in light of data from the medical literature, we discuss the embryologic origin of such malformations and the nosologic frontiers between these two diseases.

Author information

Author/s: Charlier, Philippe (P); Valat, Anne-Sylvie (AS); Boute, Odile (O); Petit, Stéphanie (S); Chafiotte, Caroline (C); Huynh-Charlier, Isabelle (I); Gosselin, Bernard (B); Devisme, Louise (L);

Affiliation: Service d'anatomie et de cytologie pathologiques, CHRU de Lille, avenue Oscar-Lambret, Lille cedex, France. ph.charlier(-atsign-)yahoo.fr

Journal and publication information

Publication Type: Case Reports; English Abstract; Journal Article

Journal: Annales de pathologie (Ann Pathol), published in France. (Language: fre)

Reference: 2008-Jun; vol 28 (issue 3) : pp 176-81

Dates: Created 2008/08/18; Completed 2008/11/05;

PMID: 18706355, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

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