Dynamic premotor-to-parietal interactions during spatial imagery.

Full Abstract

The neurobiological processes underlying mental imagery are a matter of debate and controversy among neuroscientists, cognitive psychologists, philosophers, and biologists. Recent neuroimaging studies demonstrated that the execution of mental imagery activates large frontoparietal and occipitotemporal networks in the human brain. These previous imaging studies, however, neglected the crucial interplay within and across the widely distributed cortical networks of activated brain regions. Here, we combined time-resolved event-related functional magnetic resonance imaging with analyses of interactions between brain regions (functional and effective brain connectivity) to unravel the premotor-parietal dynamics underlying spatial imagery. Participants had to sequentially construct and spatially transform a mental visual object based on either verbal or visual instructions. By concurrently accounting for the full spatiotemporal pattern of brain activity and network connectivity, we functionally segregated an early from a late premotor-parietal imagery network. Moreover, we revealed that the modality-specific information upcoming from sensory brain regions is first sent to the premotor cortex and then to the medial-dorsal parietal cortex, i.e., top-down from the motor to the perceptual pole during spatial imagery. Importantly, we demonstrate that the premotor cortex serves as the central relay station, projecting to parietal cortex at two functionally distinct stages during spatial imagery. Our approach enabled us to disentangle the multicomponential cognitive construct of mental imagery into its different cognitive subelements. We discuss and explicitly assign these mental subprocesses to each of the revealed effective brain connectivity networks and present an integrative neurobiological model of spatial imagery.

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Author information

Author/s: Sack, Alexander T (AT); Jacobs, Christianne (C); De Martino, Federico (F); Staeren, Noel (N); Goebel, Rainer (R); Formisano, Elia (E);

Affiliation: Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, 6200 MD Maastricht, The Netherlands. a.sack(-atsign-)psychology.unimaas.nl

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)

Reference: 2008-Aug; vol 28 (issue 34) : pp 8417-29

Dates: Created 2008/08/21; Completed 2008/09/16;

PMID: 18716200, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adult
Cognition - physiology
Female
Humans
Imagination - physiology
Magnetic Resonance Imaging
Male

Male
Mental Processes - physiology
Motor Cortex - physiology
Nerve Net - physiology
Parietal Lobe - physiology
Reaction Time
Synaptic Transmission

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