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| Research article summary (published 28 Aug 2008): |
Individual differences in acute alcohol impairment of inhibitory control predict ad libitum alcohol consumption.
Full Abstract
RATIONALE: Research has begun to examine how acute cognitive impairment from alcohol could contribute to alcohol abuse. Specifically, alcohol-induced impairment of inhibitory control could compromise the drinker's ability to stop the self-administration of alcohol, increasing the risk of binge drinking. OBJECTIVE: The present study was designed to test this hypothesis by examining the relation between acute alcohol impairment of inhibitory control and alcohol consumption during a single drinking episode. MATERIALS AND METHODS: Twenty-six healthy adults performed a cued go/no-go task that measured inhibitory control. The study tested the degree to which their inhibitory control was impaired by a moderate dose of alcohol (0.65 g/kg) versus a placebo and the extent to which individual differences in this impairment predicted levels of alcohol consumption as assessed by ad lib drinking in the laboratory. RESULTS: In accord with the hypothesis, greater impairment of inhibitory control from alcohol was associated with increased ad lib consumption. CONCLUSION: Acute impairment of inhibitory control might be an important cognitive effect that contributes to abuse in addition to the positive rewarding effects of the drug.
Author information
Author/s: Weafer, Jessica (J); Fillmore, Mark T (MT);
Affiliation: Department of Psychology, University of Kentucky, Lexington, KY, 40506-0044, USA.
Grants: R01 AA12895 (Agency:NIAAA NIH HHS) ; R21 DA021027 (Agency:NIDA NIH HHS)
Journal and publication information
Publication Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural
Journal: Psychopharmacology (Psychopharmacology (Berl)), published in Germany. (Language: eng)
Reference: 2008-Dec; vol 201 (issue 3) : pp 315-24
Dates: Created 2008/11/18; Completed 2009/04/07;
PMID: 18758758, status: MEDLINE (last retrieval date: 4/7/2009, IMS Date: 07 Apr 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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