Morphometric spatial patterns differentiating boys with fragile X syndrome, typically developing boys, and developmentally delayed boys aged 1 to 3 years.

Full Abstract

CONTEXT:
Brain maturation starts well before birth and occurs as a unified process with developmental interaction among different brain regions. Gene and environment play large roles in such a process. Studies of individuals with genetic disorders such as fragile X syndrome (FXS), which is a disorder caused by a single gene mutation resulting in abnormal dendritic and synaptic pruning, together with healthy individuals may provide valuable information.

OBJECTIVE:
To examine morphometric spatial patterns that differentiate between FXS and controls in early childhood.

DESIGN:
A cross-sectional in vivo neuroimaging study.

SETTING:
Academic medical centers.

PARTICIPANTS:
A total of 101 children aged 1 to 3 years, comprising 51 boys with FXS, 32 typically developing boys, and 18 boys with idiopathic developmental delay.

MAIN OUTCOME MEASURES:
Regional gray matter volume as measured by voxel-based morphometry and manual tracing, supplemented by permutation analyses; regression analyses between gray and white matter volumes, IQ, and fragile X mental retardation protein level; and linear support vector machine analyses to classify group membership.

RESULTS:
In addition to aberrant brain structures reported previously in older individuals with FXS, we found reduced gray matter volumes in regions such as the hypothalamus, insula, and medial and lateral prefrontal cortices. These findings are consistent with the cognitive and behavioral phenotypes of FXS. Further, multivariate pattern classification analyses discriminated FXS from typical development and developmental delay with more than 90% prediction accuracy. The spatial patterns that classified FXS from typical development and developmental delay included those that may have been difficult to identify previously using other methods. These included a medial to lateral gradient of increased and decreased regional brain volumes in the posterior vermis, amygdala, and hippocampus.

CONCLUSIONS:
These findings are critical in understanding interplay among genes, environment, brain, and behavior. They signify the importance of examining detailed spatial patterns of healthy and perturbed brain development.

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Author information

Author/s: Hoeft, Fumiko (F); Lightbody, Amy A (AA); Hazlett, Heather Cody (HC); Patnaik, Swetapadma (S); Piven, Joseph (J); Reiss, Allan L (AL);

Affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305-5795, USA. fumiko(-atsign-)stanford.edu

Grants: HD03110-36 (Agency:United States NICHD) ; MH61696 (Agency:United States NIMH) ; MH64708-05 (Agency:United States NIMH)

Journal and publication information

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal: Archives of general psychiatry (Arch Gen Psychiatry), published in United States. (Language: eng)

Reference: 2008-Sep; vol 65 (issue 9) : pp 1087-97

Dates: Created 2008/09/02; Completed 2008/09/26;

PMID: 18762595, status: MEDLINE (last retrieval date: 11/6/2008)

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Brain - abnormalities
Child Development - physiology
Child, Preschool
Cross-Sectional Studies
Developmental Disabilities - diagnosis; epidemiology
Fragile X Syndrome - epidemiology

Fragile X Syndrome - epidemiology
Humans
Infant
Magnetic Resonance Imaging
Male
Mental Retardation - diagnosis; epidemiology

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