Research article summary (published 9 Sep 2008):

Nutritional benefit of olive oil: the biological effects of hydroxytyrosol and its arylating quinone adducts.

Full Abstract

Olive oil is the essential component of the Mediterranean diet, a nutritional regimen gaining ever-increasing renown for its beneficial effects on inflammation, cardiovascular disease, and cancer. A unique characteristic of olive oil is its enrichment in oleuropein, a member of the secoiridoid family, which hydrolyzes to the catechol hydroxytyrosol and functions as a hydrophilic phenolic antioxidant that is oxidized to its catechol quinone during redox cycling. Little effort has been spent on exploring the biological properties of the catechol hydroxytyrosol quinone, a strong arylating electrophile that forms Michael adducts with thiol nucleophiles in glutathione and proteins. This study compares the chemical and biological characteristics of hydroxytyrosol with those of the tocopherol family in which Michael adducts of arylating desmethyltocopherol quinones have been identified and correlated with biologic properties including cytotoxicity and induction of endoplasmic reticulum stress. It is noted that hydroxytyrosol and desmethyltocopherols share many similarities, suggesting that Michael adduct formation by an arylating quinone electrophile may contribute to the biological properties of both families, including the unique nutritional benefit of olive oil.

Author information

Author/s: Cornwell, David G (DG); Ma, Jiyan (J);

Affiliation: Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA. cornwell.1(-atsign-)osu.edu

Journal and publication information

Publication Type: Journal Article; Review

Journal: Journal of agricultural and food chemistry (J Agric Food Chem), published in United States. (Language: eng)

Reference: 2008-Oct; vol 56 (issue 19) : pp 8774-86

Dates: Created 2008/10/02; Completed 2008/12/19;

PMID: 18783241, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Animals Antioxidants - administration & dosage Diet, Mediterranean Health Promotion Humans

Inflammation Neoplasms Phenylethyl Alcohol - administration & dosage; analogs & derivatives; chemistry; metabolism Plant Oils - chemistry Quinones - administration & dosage; chemistry

Associated Chemicals: Antioxidants (0) ; Plant Oils (0) ; Quinones (0) ; 3,4-dihydroxyphenylethanol (10597-60-1) ; Phenylethyl Alcohol (60-12-8) ; olive oil (8001-25-0)

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