Effect of ethanolic extract of Juglans regia L. on blood sugar in diabetes-induced rats.

Full Abstract

Walnut is one of the medicinal plants used in traditional Iranian medicine as a treatment for diabetes, but little scientific documentation supports its antidiabetic action. This study is designed to evaluate the antidiabetic effect of ethanolic walnut leaf extract. Twenty-four male Wistar rats were divided into four groups: nondiabetic rats, alloxan-induced diabetic rats with no treatment, alloxan-induced diabetic rats treated with ethanolic extracts of Juglans regia (200 mg/kg), and alloxan-induced diabetic rats treated with glibenclamide (0.6 mg/kg). Fasting blood sugar decreased meaningfully in diabetic rats treated with J. regia and diabetic rats treated with glibenclamide. Insulin level increased and glycosylated hemoglobin decreased significantly in diabetic groups receiving either glibenclamide or J. regia compared with the diabetic group with no treatment. The histological study revealed that the size of islets of Langerhans enlarged consequentially as compared with diabetic rats with no treatment. Effects of administering glibenclamide or extract of J. regia on all parameters discussed above showed no difference, and both tended to bring the values to near normal. Our data show the ethanolic extract from leaves of J. regia has a dramatic antidiabetic effect on diabetes-induced rats.

Author information

Author/s: Asgary, Sedigheh (S); Parkhideh, Sahar (S); Solhpour, Amirreza (A); Madani, Hossein (H); Mahzouni, Parvin (P); Rahimi, Parivash (P);

Affiliation: Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. s_asgari(-atsign-)crc.mui.ac.ir

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of medicinal food (J Med Food), published in United States. (Language: eng)

Reference: 2008-Sep; vol 11 (issue 3) : pp 533-8

Dates: Created 2008/09/19; Completed 2009/02/03;

PMID: 18800903, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Alloxan
Animals
Blood Glucose - drug effects
Diabetes Mellitus, Experimental - blood; drug therapy
Glyburide - pharmacology; therapeutic use
Hypoglycemic Agents - pharmacology; therapeutic use
Insulin - blood
Islets of Langerhans - physiopathology

Islets of Langerhans - physiopathology
Juglans - chemistry
Lipids - blood
Male
Phytotherapy
Plant Extracts - pharmacology; therapeutic use
Plant Leaves - chemistry
Rats

Associated Chemicals: Blood Glucose (0) ; Hypoglycemic Agents (0) ; Lipids (0) ; Plant Extracts (0) ; Glyburide (10238-21-8) ; Insulin (11061-68-0) ; Alloxan (50-71-5)

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