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[Effect of the sera of rabbits fed with Tongxinluo on MMP-9 and TIMP-1 expression and secretion in U937 monocyte-derived macrophages]
Full Abstract
OBJECTIVE: To investigate the effect of the sera of rabbits fed with Tongxinluo on the expression and secretion of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in U937 monocyte-derived macrophages. METHODS: Atherosclerosis was induced in rabbits by high-cholesterol feeding, and the serum was obtained from the rabbits after administration of the aqueous solution of Tongxinluo or simvastatin by gavage. U937 monocyte-derived macrophages were incubated with the sera at different concentrations for 24 hours, and the changes in MMP-9 and TIMP-1 gene expression and secretion were detected by RT-PCR and enzyme-linked immunosorbent assay, respectively. RESULTS: The serum of rabbits fed with Tongxinluo concentration-dependently inhibited the expression and secretion of MMP-9 in U937 macrophages, but did not affect TIMP-1 expression or secretion. CONCLUSION: Tongxinluo may stabilize the atherosclerotic plaques by inhibiting the expression and secretion of MMP-9.
Author information
Author/s: Liu, Jin-lai (JL); Zhu, Qiang-feng (QF); Hao, Bao-shun (BS);
Affiliation: Department of Cardiology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. lj.lai(-atsign-)medmail.com.cn
Journal and publication information
Publication Type: English Abstract; Journal Article
Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University (Nan Fang Yi Ke Da Xue Xue Bao), published in China. (Language: chi)
Reference: 2008-Aug; vol 28 (issue 9) : pp 1703-6
Dates: Created 2008/09/29; Completed 2009/04/06;
PMID: 18819903, status: MEDLINE (last retrieved date: 4/6/2009)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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Associated Chemicals: Cholesterol, Dietary (0) ; Drugs, Chinese Herbal (0) ; RNA, Messenger (0) ; Tissue Inhibitor of Metalloproteinase-1 (0) ; tongxinluo (0) ; Matrix Metalloproteinase 9 (EC 3.4.24.35)Related articles
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