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| Research article summary (published 27 Feb 2009): |
Antiamnesic potential of Murraya koenigii leaves.
Full Abstract
Murraya koenigii leaves commonly known as curry patta are added routinely to Indian gravy and vegetarian dishes as a favorite condiment. The effects of Murraya koenigii leaves (MKL) on cognitive functions, total serum cholesterol level and brain cholinesterase activity in young and aged mice fed orally with a diet containing 2%, 4% and 8% w/w of MKL for 30 days consecutively, were investigated. The memory scores were measured using various exteroceptive and interoceptive behavioral models. The MKL diets produced a significant dose-dependent improvement in the memory scores of young and aged mice and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Also, brain cholinesterase activity and total cholesterol levels were reduced by the MKL diets. The underlying mechanism of action for the observed nootropic effect may be attributed to pro-cholinergic activity and a cholesterol lowering property. Therefore, it would be worthwhile to investigate specifically the therapeutic potential of MKL in the management of Alzheimer patients. (c) 2008 John Wiley & Sons, Ltd.
Author information
Author/s: Vasudevan, Mani (M); Parle, Milind (M);
Affiliation: Department of Pharmacology, Nandha College of Pharmacy, Koorapalayam Pirivu, Pitchandampalayam (PO), Erode-District, Tamilnadu 638 052, India. vasumpharmacol(-atsign-)yahoo.co.uk
Journal and publication information
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal: Phytotherapy research : PTR (Phytother Res), published in England. (Language: eng)
Reference: 2009-Mar; vol 23 (issue 3) : pp 308-16
Dates: Created 2009/03/03; Completed 2009/03/30;
PMID: 18844259, status: MEDLINE (last retrieval date: 3/30/2009, IMS Date: 30 Mar 2009 00:00:00)
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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