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Dopaminergic suppression of brain deactivation responses during sequence learning.
Full Abstract
Cognitive processing is associated with deactivation of the default mode network. The presence of dopaminoceptive neurons in proximity to the medial prefrontal node of this network suggests that this neurotransmitter may modulate deactivation in this region. We therefore used positron emission tomography to measure cerebral blood flow in 15 Parkinson's disease (PD) patients while they performed a motor sequence learning task and a simple movement task. Scanning was conducted before and during intravenous levodopa infusion; the pace and extent of movement was controlled across tasks and treatment conditions. In normal and unmedicated PD patients, learning-related deactivation was present in the ventromedial prefrontal cortex (p < 0.001). This response was absent in the treated condition. Treatment-mediated changes in deactivation correlated with baseline performance (p < 0.002) and with the val(158)met catechol-O-methyltransferase genotype. Our findings suggest that dopamine can influence prefrontal deactivation during learning, and that these changes are linked to baseline performance and genotype.
Author information
Author/s: Argyelan, Miklos (M); Carbon, Maren (M); Ghilardi, Maria-Felice (MF); Feigin, Andrew (A); Mattis, Paul (P); Tang, Chengke (C); Dhawan, Vijay (V); Eidelberg, David (D);
Affiliation: Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore University Hospital, Manhasset, New York 11030, USA.
Grants: M01 RR018535 (Agency:NCRR NIH HHS) ; R01 35069 (Agency:PHS HHS)
Journal and publication information
Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience (J Neurosci), published in United States. (Language: eng)
Reference: 2008-Oct; vol 28 (issue 42) : pp 10687-95
Dates: Created 2008/10/16; Completed 2008/10/29;
PMID: 18923044, status: MEDLINE (last retrieval date: 2/18/2009, IMS Date: )
Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.
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