Computerized 2-lead resting ECG analysis for the detection of relevant coronary artery stenosis in comparison with angiographic findings.

Full Abstract

To assess the sensitivity and specificity of a new computer-enhanced resting electrocardiographic analysis device for the detection of coronary stenosis, 189 patients (aged 61.3+/-12.9 years, 57 women) scheduled for coronary angiography from 4 Asian centers were included in an observational study. Angiographic results were independently classified for hemodynamically relevant stenosis by 2 angiographers. The device calculated a severity score from 0 to 20. The score was significantly higher for patients with coronary stenosis (5.4+/-1.8 vs 1.7+/-2.1). The study device (cutoff 4.0) identified 73 of 77 patients with stenosis (sensitivity 94.8%, specificity 86.6%). Adjusted positive and negative predictive values were 78.4% and 97.1%, respectively (receiver operating characteristic area under the curve, 0.914 [95% confidence interval, 0.868-0.961]). Subgroup analysis showed no significant influence of sex, age, previous revascularization procedures, or participating center. The new computer-enhanced, resting electrocardiographic analysis device appears to identify patients with relevant coronary stenosis with high sensitivity and specificity.

Author information

Author/s: Hosokawa, Joji (J); Shen, Joseph T (JT); Imhoff, Michael (M);

Affiliation: From the Tokyo Heart Center, Kita-shinagawa, Shinagawa, Tokyo, Japan.

Journal and publication information

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal: Congestive heart failure (Greenwich, Conn.) (Congest Heart Fail), published in United States. (Language: eng)

Reference: -2008 Sep-Oct; vol 14 (issue 5) : pp 251-60

Dates: Created 2008/11/05; Completed 2009/01/07;

PMID: 18983288, status: MEDLINE (last retrieved date: 2/18/2009)

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