Cytoplasmic LRIG2 expression is associated with poor oligodendroglioma patient survival.

Full Abstract

The three leucine-rich repeats and immunoglobulin-like domains (LRIG) genes encode integral membrane proteins. Of these, LRIG1 negatively regulates growth factor signaling and is implicated as a tumor suppressor in certain malignancies. In astrocytic tumors, the subcellular distribution of LRIG proteins is associated with specific clinicopathological features and patient survival. The role of LRIG proteins in oligodendroglioma has not previously been studied. Here we used immunohistochemistry to analyze the expression of the LRIG proteins in 63 oligodendroglial tumors, and evaluated possible associations between LRIG protein expression and clinicopathological parameters. Notably, cytoplasmic LRIG2 expression was found to be an independent prognostic factor associated with poor oligodendroglioma patient survival. This is the first report of an LRIG protein showing a negative effect on survival, suggesting that LRIG2 might have a function different from that of LRIG1, and possibly contributing to the etiology of oligodendroglioma.

Author information

Author/s: Holmlund, Camilla (C); Haapasalo, Hannu (H); Yi, Wei (W); Raheem, Olayinka (O); Brännström, Thomas (T); Bragge, Helena (H); Henriksson, Roger (R); Hedman, Håkan (H);

Affiliation: Departments of Radiation Sciences, Oncology, Umeå University, Sweden.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Neuropathology : official journal of the Japanese Society of Neuropathology (Neuropathology), published in Australia. (Language: eng)

Reference: 2009-Jun; vol 29 (issue 3) : pp 242-7

Dates: Created 2009/08/03; Completed 2009/10/19;

PMID: 18992012, status: MEDLINE (last retrieval date: 10/19/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

External Links for this article
(including full text providers, if available):

Click Electronic Full-text Provider Links to see options for finding the electronic full text links to this article. Note there may be a subscription or fee required for access to the full text. See our FAQ for information on finding FREE full text articles.

This article may also be located in paper journal collections available in many libraries. Use the Journal and Publication Information above to find the full article.

MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Adolescent
Adult
Aged
Brain Neoplasms - diagnosis; metabolism; pathology
Cell Nucleus - metabolism
Cytoplasm - metabolism
Female
Humans
Kaplan-Meiers Estimate

Kaplan-Meiers Estimate
Male
Membrane Glycoproteins - metabolism
Membrane Proteins - metabolism
Middle Aged
Neoplasm Staging
Oligodendroglioma - diagnosis; metabolism; pathology
Prognosis
Young Adult

Associated Chemicals: LRIG1 protein, human (0) ; LRIG2 protein, human (0) ; LRIG3 protein, human (0) ; Membrane Glycoproteins (0) ; Membrane Proteins (0)

These are the highest related articles currently in the database: