Research article summary (published 29 Nov 2008):

Human papillomavirus in HNSCC: recognition of a distinct disease type.

Full Abstract

Strong epidemiologic and molecular data now support the conclusion that human papillomavirus (HPV) infection is responsible for a distinct form of head and neck squamous cell carcinoma (HNSCC), independent from the traditional risk factors of tobacco and alcohol use. Patients with HPV-positive HNSCC have a different clinical presentation and better clinical outcomes than those with HPV-negative HNSCC. A diagnosis of HPV-positive HNSCC is associated not only with therapeutic relevance, but also has important implications for future prevention and screening strategies.

Author information

Author/s: Vidal, Laura (L); Gillison, Maura L (ML);

Affiliation: Department of Medical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.

Journal and publication information

Publication Type: Journal Article; Review

Journal: Hematology/oncology clinics of North America (Hematol Oncol Clin North Am), published in United States. (Language: eng)

Reference: 2008-Dec; vol 22 (issue 6) : pp 1125-42, vii

Dates: Created 2008/11/17; Completed 2009/02/17;

PMID: 19010263, status: MEDLINE (last retrieved date: 3/9/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Adult Cell Transformation, Viral - genetics Female Human papillomavirus 16 - genetics; metabolism Humans Male Middle Aged Mouth Neoplasms - diagnosis; epidemiology; genetics; metabolism; therapy; virology Neoplasms, Squamous Cell - diagnosis; epidemiology; genetics; metabolism; therapy; virology

Neoplasms, Squamous Cell - diagnosis; epidemiology; genetics; metabolism; therapy; virology Oncogene Proteins, Viral - genetics; metabolism Papillomavirus Infections - diagnosis; epidemiology; genetics; metabolism; therapy Prognosis Repressor Proteins - genetics; metabolism Retinoblastoma Protein - genetics; metabolism Sexually Transmitted Diseases - diagnosis; epidemiology; genetics; metabolism; therapy; virology Tumor Suppressor Protein p53 - genetics; metabolism United States - epidemiology

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: E6 protein, Human papillomavirus type 16 (0) ; Oncogene Proteins, Viral (0) ; Repressor Proteins (0) ; Retinoblastoma Protein (0) ; TP53 protein, human (0) ; Tumor Suppressor Protein p53 (0) ; oncogene protein E7, Human papillomavirus type 16 (0)

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