Long-term caffeine consumption reverses tumor-induced suppression of the innate immune response in adult mice.

Full Abstract

Caffeine (1,3,7-trimethylxanthine), the active principle alkaloid of coffee ( Coffea arabica) and tea ( Camellia sinensis) possesses a restraining effect on tumor-induced suppression of the specific immune response in adult mice. The present study deals with the effect of long-term consumption of caffeine in the development of Ehrlich ascites carcinoma (EAC) cells in adult Swiss female mice, in relation to the innate immune response and tumor growth. Although the consumption of caffeine alone for more than 12 consecutive days did not affect the innate immune response parameters, continuation of its treatment following intraperitoneal EAC cell inoculation not only reduced the IN VIVO tumor growth but also reduced/restored the EAC cell-induced suppression of the innate immune response. These results suggest that caffeine may inhibit IN VIVO tumor growth through reduction of the cancer cell-induced suppression of the innate immune response. CNS:central nervous system EAC:Ehrlich ascites carcinoma ESR:erythrocyte sedimentation rate GABA:gamma-aminobutyric acid Hb:hemoglobin HPA:hypothalamic-pituitary-adrenal HPG:hypothalamic-pituitary-gonadal PCV:packed cell volume RBC:red blood cell WBC:white blood cell.

Author information

Author/s: Mandal, Anup (A); Poddar, Mrinal K (MK);

Affiliation: Department of Biochemistry, University of Calcutta, Kolkata, India.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Planta medica (Planta Med), published in Germany. (Language: eng)

Reference: 2008-Dec; vol 74 (issue 15) : pp 1779-84

Dates: Created 2008/12/16; Completed 2009/03/20;

PMID: 19016405, status: MEDLINE (last retrieved date: 3/20/2009)

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MeSH Headings (categories) shown below.

Animals
Blood Cell Count
Blood Sedimentation - drug effects
Body Weight - drug effects
Caffeine - therapeutic use
Camellia sinensis
Carcinoma, Ehrlich Tumor - drug therapy; immunology
Coffea

Disease Models, Animal
Female
Hematocrit
Hemoglobins - drug effects
Immunity, Innate - drug effects
Immunologic Factors - therapeutic use
Mice
Phytotherapy

Note: Bold headings indicate primary MeSH headings or qualifiers.

Associated Chemicals: Hemoglobins (0) ; Immunologic Factors (0) ; Caffeine (58-08-2)

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