Research article summary (published Nov 2009):

Subcortical vascular versus amnestic mild cognitive impairment: comparison of cerebral glucose metabolism.

Full Abstract

BACKGROUND AND PURPOSE: Most studies on mild cognitive impairment (MCI) have been focused on amnestic MCI (aMCI) that is the preclinical stage of Alzheimer's disease (AD). In contrast, only a few studies have involved patients in the preclinical stages of subcortical vascular dementia (subcortical vascular MCI, svMCI). We tried to compare the overall glucose metabolism in patients with svMCI with that of patients with aMCI. METHODS: We compared the regional metabolic patterns shown on 18 F-FDG (fluro deoxy glucose) positron emission tomography (PET) images from 18 patients with svMCI with those from 25 aMCI patients matched for age, sex, education, and mini-mental state examination (MMSE) score and with those from 35 healthy subjects using a voxel-wise analysis. SPM 2 was used for statistical analysis. RESULTS: Relative to normal controls, the hypometabolic regions in the aMCI patients were in the bilateral parahippocampal, bilateral posterior cingulate, left superior temporal gyri, left inferior parietal lobule, and right inferior frontal gyrus while those in the svMCI patients were located in the thalamus, insula, superior temporal gyrus, anterior cingulate gyrus, cingulum, right basal ganglia, cerebellum, and brainstem. A direct comparison of glucose metabolism between svMCI and aMCI showed that the glucose hypometabolism in patients with svMCI was more severe in the thalamus, brainstem, and cerebellum. CONCLUSION: Our study suggested that svMCI was distinct from aMCI in terms of neuropsychological and PET findings, which may explain their clinical manifestations.

Author information

Author/s: Seo, Sang Won (SW); Cho, Sang Soo (SS); Park, Aram (A); Chin, Juhee (J); Na, Duk L (DL);

Affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Journal and publication information

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal: Journal of neuroimaging : official journal of the American Society of Neuroimaging (J Neuroimaging), published in United States. (Language: eng)

Reference: 2009-Jul; vol 19 (issue 3) : pp 213-9

Dates: Created 2009/07/14; Completed 2009/10/09;

PMID: 19021838, status: MEDLINE (last retrieval date: 10/9/2009, IMS Date: )

Sourced from the National Library of Medicine. Abstract text and other information may be subject to copyright.

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MeSH headings (categories)

This article was linked to the MESH Headings shown below.

Aged Brain - metabolism; radionuclide imaging Brain Mapping Cognition Disorders - metabolism; radionuclide imaging Female Fluorodeoxyglucose F18

Fluorodeoxyglucose F18 Glucose - metabolism Humans Male Neuropsychological Tests Positron-Emission Tomography

Associated Chemicals: Glucose (50-99-7) ; Fluorodeoxyglucose F18 (63503-12-8)

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